The control and facilitation of MHC class II antigen processing by the BCR

Antigens capable of cross-linking the BCR are preferentially captured, processed and presented to MHC-class-II-restricted T cells. Cross-linking antigens initiate tyrosine-kinase-dependent pathways that accelerate the delivery of antigen–receptor complexes to specialized late-endocytic processing co...

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Bibliographic Details
Published in:Current Opinion in Immunology 2001-02, Vol.13 (1), p.32-36
Main Authors: Siemasko, Karyn, Clark, Marcus R
Format: Article
Language:English
Subjects:
Animals
Antigen presentatiob
Antigen Presentation - immunology
antigen processing
BCR
BLNK
Histocompatibility Antigens Class II - immunology
Histocompatibility Antigens Class II - metabolism
Humans
MIIC
Receptors, Antigen, B-Cell - physiology
Signaling
Trafficking
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Summary:Antigens capable of cross-linking the BCR are preferentially captured, processed and presented to MHC-class-II-restricted T cells. Cross-linking antigens initiate tyrosine-kinase-dependent pathways that accelerate the delivery of antigen–receptor complexes to specialized late-endocytic processing compartments. Accelerated trafficking is mediated by the recruitment of signaling molecules required for transience through specific checkpoints along the endocytic pathway.
ISSN:0952-7915
1879-0372
DOI:10.1016/S0952-7915(00)00178-3