Rat Small Intestine Muscle Relaxation Alkaloids from Orixa japonica Leaves

Two quinoline alkaloids, japonine (1) and eduline (2) were isolated from the methanol extract of the leaves of Orixa japonica as relaxants against rat small intestine muscle. The activity of these alkaloids was comparable to that of the typical muscle relaxant papaverine (4). This is also the first...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 2001, Vol.24(1), pp.100-102
Main Authors: FUNAYAMA, Shinji, TANAKA, Rioko, KUMEKAWA, Yasuhiro, NOSHITA, Toshiro, MORI, Tetsuya, KASHIWAGURA, Tadashi, MURATA, Kiyoshi
Format: Article
Language:English
Subjects:
Alkaloids - isolation & purification
Alkaloids - pharmacology
Animals
Biological and medical sciences
eduline
General pharmacology
japonine
Jejunum - drug effects
Jejunum - physiology
Medical sciences
Muscle
Muscle Relaxation - drug effects
Orixa japonica
PC12 Cells
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
quinoline alkaloid
Quinolines - isolation & purification
Quinolines - pharmacology
rat small intestine
Rats
relaxant effect
Rosales - chemistry
Spectrum Analysis
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Summary:Two quinoline alkaloids, japonine (1) and eduline (2) were isolated from the methanol extract of the leaves of Orixa japonica as relaxants against rat small intestine muscle. The activity of these alkaloids was comparable to that of the typical muscle relaxant papaverine (4). This is also the first report of the isolation of eduline (2) from O. japonica.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.24.100