62Cu-PTSM and PET used for the assessment of angiotensin II-induced blood flow changes in patients with colorectal liver metastases

The aim of this study was to establish a quantitative positron emission tomography (PET) method for investigating angiotensin II (AII)-induced changes in blood flow distribution in the liver. This was in order to evaluate the role of vascular manipulation applied to locoregional chemotherapy treatme...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 2001, Vol.28 (1), p.99-103
Main Authors: FLOWER, Maggie A, ZWEIT, Jamal, CARNOCHAN, Paul, ALLEN-MERSH, Timothy G, HALL, Adrian D, BURKE, Dermot, DAVIES, Michael M, DWORKIN, Michael J, YOUNG, Helen E, MUNDY, John, OTT, Robert J, MCCREADY, V. Ralph
Format: Article
Language:English
Subjects:
Algorithms
Angiotensin II - pharmacology
Biological and medical sciences
Calibration
Colorectal Neoplasms - pathology
Copper Radioisotopes
Digestion. Liver. Biliary tract. Spleen. Pancreas
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Image Processing, Computer-Assisted
Investigative techniques, diagnostic techniques (general aspects)
Liver - diagnostic imaging
Liver Circulation - drug effects
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - secondary
Medical sciences
Organometallic Compounds
Radionuclide investigations
Radiopharmaceuticals
Reproducibility of Results
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Thiosemicarbazones
Tomography, Emission-Computed
Tumors
Vasoconstrictor Agents - pharmacology
Zinc Radioisotopes
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Summary:The aim of this study was to establish a quantitative positron emission tomography (PET) method for investigating angiotensin II (AII)-induced changes in blood flow distribution in the liver. This was in order to evaluate the role of vascular manipulation applied to locoregional chemotherapy treatment in patients with colorectal liver metastases. The tracer selected was copper-62 (II) pyruvaldehyde bis-(N4-methyl)thiosemicarbazone (62Cu-PTSM), which exhibits high first-pass extraction and tissue retention following intra-arterial administration. The short half-life of the tracer and its availability from a 62Zn/62Cu generator enabled short-interval repeat PET scans on patients in a single imaging session. Distribution of tracer within the liver was imaged in a single view using a PET camera with rotating large-area detectors. By optimisation of the acquisition protocol, it was possible to acquire sufficient data to produce good-quality images and to quantify tracer uptake with an accuracy of
ISSN:0340-6997
1619-7070
1619-7089
DOI:10.1007/s002590000410