Laterality of interhemispheric inhibition depends on handedness

There is some evidence that handedness is related to lateralisation of excitability in the motor system. We investigated lateralisation of interhemispheric inhibition (IHI), motor thresholds and short interval intracortical inhibition (SICI) and facilitation (SICF) in relation to handedness in 12 ri...

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Bibliographic Details
Published in:Experimental brain research 2007-06, Vol.180 (2), p.195-203
Main Authors: BÄUMER, T, DAMMANN, E, BOCK, F, KLÖPPEL, S, SIEBNER, H. R, MUNCHAU, A
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Anatomical correlates of behavior
Behavioral psychophysiology
Biological and medical sciences
Brain Mapping
Central nervous system
Central neurotransmission. Neuromudulation. Pathways and receptors
Cerebral hemispheres
Cortex (motor)
Cortex (premotor)
Electric Stimulation
Evoked Potentials, Motor - physiology
Excitability
Experiments
Female
Functional Laterality - physiology
Fundamental and applied biological sciences. Psychology
Handedness
Hemispheric laterality
Humans
Male
Motor Cortex - physiology
Neural Inhibition - physiology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rest - physiology
Time Factors
Transcranial Magnetic Stimulation
Vertebrates: nervous system and sense organs
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Summary:There is some evidence that handedness is related to lateralisation of excitability in the motor system. We investigated lateralisation of interhemispheric inhibition (IHI), motor thresholds and short interval intracortical inhibition (SICI) and facilitation (SICF) in relation to handedness in 12 right (RH) and 13 left handed (LH) subjects. Because there is some controversy as to the optimal localisation to produce IHI we also compared IHI induced by conditioning the dorsal premotor cortex (dPM) versus primary motor cortex (M1) in ten RH. IHI was stronger following conditioning the motor dominant as compared to the motor non-dominant hemisphere in RH and LH. Motor thresholds were higher when elicited over the right hemisphere than over the left in both RH and LH, while SICI and SICF showed no differences between hemispheres or dependency from handedness. We hypothesize that IHI is a function of handedness perhaps reflecting predominant usage of the dominant hand, while lateralisation of thresholds and intracortical excitability are determined by other factors.
ISSN:0014-4819
1432-1106
DOI:10.1007/s00221-007-0866-7