IL4-R1 (5q31-q33) and FcepsilonRI-betaca (11q13) markers and atopy: a case/control study in a spanish population

Rhinoconjunctivitis and bronchial asthma are atopic diseases with a high prevalence in the Canary Islands (Spain). Given that the most prevalent allergen is the house-dust mite Dermatophagoides pteronyssinus, early detection of genetically susceptible subjects would allow the application of preventi...

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Bibliographic Details
Published in:Allergy (Copenhagen) 2001-02, Vol.56 (2), p.159-163
Main Authors: Torres-Galván, M J, Quiralte, J, Pestano, J J, Ortega, N, Blanco, C, Castillo, R, Carrillo, T, Pérez-Aciego, P, Sánchez-García, F
Format: Article
Language:English
Subjects:
Adult
Antigens, Dermatophagoides
Asthma - immunology
Case-Control Studies
Chromosomes, Human, Pair 11 - genetics
Chromosomes, Human, Pair 5 - genetics
Conjunctivitis - immunology
Female
Glycoproteins - immunology
Humans
Hypersensitivity - complications
Hypersensitivity - genetics
Male
Microsatellite Repeats
Receptors, IgE - genetics
Receptors, Interleukin-4 - genetics
Rhinitis - immunology
Skin Tests
Spain
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Summary:Rhinoconjunctivitis and bronchial asthma are atopic diseases with a high prevalence in the Canary Islands (Spain). Given that the most prevalent allergen is the house-dust mite Dermatophagoides pteronyssinus, early detection of genetically susceptible subjects would allow the application of preventive measures. The objective was to investigate the possible association of IL4-R1 (chromosome 5q31-q33) and FcepsilonRI-betaca (chromosome 11q13) markers with the atopic disease in our population. We performed a case/control study in which patients were recruited on the basis of diagnosis of rhinoconjunctivitis and/or bronchial asthma, and positive skin prick test to D. pteronyssinus. Analysis of IL4-R1 and FcepsilonRI-betaca microsatellites was carried out by PCR and electrophoresis in acrylamide gels. We have not found evidence of association between IL4-R1 and FcepsilonRI-betaca markers and atopic disease in our population. In addition, these markers have shown a high percentage of homozygosis. IL4-R1 and FcepsilonRI-betaca markers have not proved to be useful genetic markers for linkage or association studies in our population.
ISSN:0105-4538