Three Cases of Cytomegalovirus Infection Following Pancreatic Islet Transplantation

Abstract Transmission of cytomegalovirus (CMV) is uncommon in patients transplanted with CMV-mismatched pancreatic islets, and CMV-seropositive recipients rarely experience reactivation of the virus or reinfection from a CMV-positive graft. This study describes three cases of CMV infection following...

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Bibliographic Details
Published in:Transplantation proceedings 2007-06, Vol.39 (5), p.1599-1603
Main Authors: Yakubovich, N, Fung, M.A, Thompson, D.M
Format: Article
Language:English
Subjects:
Antiviral Agents - therapeutic use
Biological and medical sciences
Cytomegalovirus Infections - diagnosis
Cytomegalovirus Infections - drug therapy
Cytomegalovirus Infections - prevention & control
Cytomegalovirus Infections - transmission
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Ganciclovir - therapeutic use
Humans
Immunoglobulins, Intravenous - therapeutic use
Islets of Langerhans Transplantation - adverse effects
Medical sciences
Recurrence
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tissue, organ and graft immunology
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Summary:Abstract Transmission of cytomegalovirus (CMV) is uncommon in patients transplanted with CMV-mismatched pancreatic islets, and CMV-seropositive recipients rarely experience reactivation of the virus or reinfection from a CMV-positive graft. This study describes three cases of CMV infection following islet transplantation for type 1 diabetes despite prophylaxis with valganciclovir. Further studies are needed to evaluate risk factors for CMV transmission and reactivation in this patient population.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2007.01.074