Increased plasma levels of visfatin/pre-B cell colony-enhancing factor in obese and overweight patients with metabolic syndrome

Visfatin [pre-B cell colony- enhancing factor (PBEF)] is a cytokine highly expressed in visceral fat that exhibits insulin-mimetic properties. However, its role in insulin-resistant states, such as in metabolic syndrome (MetS), remains largely unknown. To investigate the possible differences of plas...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2007-04, Vol.30 (4), p.323-326
Main Authors: Filippatos, T D, Derdemezis, C S, Kiortsis, D N, Tselepis, A D, Elisaf, M S
Format: Article
Language:English
Subjects:
Adult
Body Mass Index
Case-Control Studies
Cytokines - blood
Female
Humans
Male
Metabolic Syndrome - blood
Metabolic Syndrome - complications
Metabolic Syndrome - diagnosis
Middle Aged
Nicotinamide Phosphoribosyltransferase
Obesity - blood
Obesity - complications
Overweight
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Summary:Visfatin [pre-B cell colony- enhancing factor (PBEF)] is a cytokine highly expressed in visceral fat that exhibits insulin-mimetic properties. However, its role in insulin-resistant states, such as in metabolic syndrome (MetS), remains largely unknown. To investigate the possible differences of plasma visfatin levels between obese and overweight subjects with and without MetS. Plasma visfatin concentrations were measured with enzyme-linked immunosorbent assay (ELISA) in 28 overweight and obese [body mass index (BMI)>28 kg/m2] subjects with Mets and 28 age- and sex-matched overweight and obese (BMI>28 kg/m2) individuals without MetS (control group). Patients with MetS exhibited significantly elevated waist circumference (WCR ) values, higher blood pressure readings, higher fasting glucose and triglyceride concentrations as well as lower levels of HDL cholesterol (HDL-C) compared with controls. Total and LDL cholesterol (LDL-C) concentrations did not differ significantly between the two groups. Plasma visfatin concentrations were significantly higher in subjects with MetS compared with controls [27 (16- 65) ng/ml vs 19 (10-47) ng/ml, p
ISSN:0391-4097
1720-8386
DOI:10.1007/BF03346300