Near-normoglycaemic remission in African-Americans with Type 2 diabetes mellitus is associated with recovery of beta cell function

SUMMARY Aims  To prospectively determine the frequency of remission and possible mechanism of beta cell recovery in non‐Whites with Type 2 diabetes mellitus in the setting of intensive glycaemic regulation using pharmacological agents. Methods  Twenty‐six consecutive, newly diagnosed African‐America...

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Bibliographic Details
Published in:Diabetic medicine 2001-01, Vol.18 (1), p.10-16
Main Authors: McFarlane, S. I., Chaiken, R. L., Hirsch, S., Harrington, P., Lebovitz, H. E., Banerji, M. A.
Format: Article
Language:English
Subjects:
African Americans
African Continental Ancestry Group
Aged
beta cell recovery
Biological and medical sciences
Biomarkers - blood
Blood Glucose - metabolism
C-Peptide - blood
C-Peptide - metabolism
Combined Modality Therapy
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - physiopathology
Diabetes Mellitus, Type 2 - therapy
Diabetes. Impaired glucose tolerance
Diet, Diabetic
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Female
Follow-Up Studies
Glyburide - therapeutic use
Glycated Hemoglobin A - analysis
Humans
Hyperglycemia
Hypoglycemic Agents - therapeutic use
Insulin - blood
Insulin - metabolism
Insulin - therapeutic use
Insulin Secretion
Islets of Langerhans - physiopathology
Male
Management. Various non-drug treatments. Langerhans islet grafts
Medical sciences
Middle Aged
New York City
Patient Education as Topic
Prospective Studies
remission
Time Factors
treatment
type 2 diabetes
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Summary:SUMMARY Aims  To prospectively determine the frequency of remission and possible mechanism of beta cell recovery in non‐Whites with Type 2 diabetes mellitus in the setting of intensive glycaemic regulation using pharmacological agents. Methods  Twenty‐six consecutive, newly diagnosed African‐American, Type 2 diabetic patients presenting primarily for severe hyperglycaemia (31.0 ± 12.8 mmol/l) were followed for at least 1 year. Initial hospitalization included treatment with insulin, fluids and electrolytes. Outpatient intensive glycaemic regulation included insulin or glibenclamide, diabetes education and diet that altered nutrient content. Plasma glucose and C‐peptide responses to an oral glucose tolerance test and HbA1c were measured at
ISSN:0742-3071
1464-5491
DOI:10.1046/j.1464-5491.2001.00395.x