Preparation and antibacterial activity evaluation of rifampicin-loaded poly lactide-co-glycolide nanoparticles

Abstract Biodegradable polymers such as poly lactide-co-glycolides (PLGA) have been considered for the preparation of nanoparticles (NPs). In this study, rifampicin (RIF)-loaded PLGA NPs were fabricated by an emulsification/solvent diffusion method. The effect of several variables on the NPs' c...

Full description

Saved in:
Bibliographic Details
Published in:Nanomedicine 2007-06, Vol.3 (2), p.161-167
Main Authors: Esmaeili, Farnaz, PharMD, Hosseini-Nasr, Mahdi, Rad-Malekshahi, Mazda, Samadi, Nasrin, PhD, Atyabi, Fatemeh, PhD, Dinarvand, Rassoul, PhD
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - chemistry
Antibacterial activity
Antimicrobial delivery
Bacteria - cytology
Bacteria - drug effects
Cell Survival - drug effects
Coated Materials, Biocompatible - chemistry
Drug Carriers - chemistry
Internal Medicine
Lactic Acid - chemistry
Materials Testing
Nanoparticles
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Poly lactide-co-glycolide
Polyglycolic Acid - chemistry
Polymers - chemistry
Rifampicin
Rifampin - administration & dosage
Rifampin - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Biodegradable polymers such as poly lactide-co-glycolides (PLGA) have been considered for the preparation of nanoparticles (NPs). In this study, rifampicin (RIF)-loaded PLGA NPs were fabricated by an emulsification/solvent diffusion method. The effect of several variables on the NPs' characteristics were evaluated, including the amount of RIF, amount of the poly vinyl alcohol as surfactant, and internal-phase volume and composition. The RIF encapsulation efficacy and the particle size distribution were optimized by varying these parameters. NPs were spherical with a relatively monodispersed size distribution. The effect of nanoencapsulation of RIF on the antibacterial activity of RIF against gram-positive and gram-negative bacteria was evaluated. It was shown that RIF NPs could considerably improve the RIF antibacterial efficacy.
ISSN:1549-9634
1549-9642
DOI:10.1016/j.nano.2007.03.003