Forensic DNA Analysis on Microfluidic Devices: A Review

:  The advent of microfluidic technology for genetic analysis has begun to impact forensic science. Recent advances in microfluidic separation of short‐tandem‐repeat (STR) fragments has provided unprecedented potential for improving speed and efficiency of DNA typing. In addition, the analytical pro...

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Bibliographic Details
Published in:Journal of forensic sciences 2007-07, Vol.52 (4), p.784-799
Main Authors: Horsman, Katie M., Bienvenue, Joan M., Blasier, Kiev R., Landers, James P.
Format: Article
Language:English
Subjects:
DNA Fingerprinting - instrumentation
DNA Fingerprinting - methods
DNA fingerprints
DNA typing
Efficiency
Female
forensic science
Forensic sciences
Forensic Sciences - instrumentation
Forensic Sciences - methods
Gene amplification
Genetic testing
Humans
Male
microchip technology
Microfluidic Analytical Techniques - instrumentation
Microfluidic Analytical Techniques - methods
microfluidics
Research methodology
Tandem Repeat Sequences
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Summary::  The advent of microfluidic technology for genetic analysis has begun to impact forensic science. Recent advances in microfluidic separation of short‐tandem‐repeat (STR) fragments has provided unprecedented potential for improving speed and efficiency of DNA typing. In addition, the analytical processes associated with sample preparation––which include cell sorting, DNA extraction, DNA quantitation, and DNA amplification––can all be integrated with the STR separation in a seamless manner. The current state of these microfluidic methods as well as their advantages and potential shortcomings are detailed. Recent advances in microfluidic device technology, as they pertain to forensic DNA typing, are discussed with a focus on the forensic community.
ISSN:0022-1198
1556-4029
DOI:10.1111/j.1556-4029.2007.00468.x