Highly Enantioselective Organocatalytic Direct Aldol Reaction in an Aqueous Medium

We have demonstrated that small organic molecules 1 and 2 catalyzed the direct aldol reaction of both acyclic and cyclic ketones with different aldehydes in an excess of water/brine. Excellent enantioselectivities up to >99% and diastereoselectivities up to 99% with very good yields were obtained...

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Bibliographic Details
Published in:Organic letters 2007-06, Vol.9 (13), p.2593-2595
Main Authors: Maya, Vishnu, Raj, Monika, Singh, Vinod K
Format: Article
Language:English
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Summary:We have demonstrated that small organic molecules 1 and 2 catalyzed the direct aldol reaction of both acyclic and cyclic ketones with different aldehydes in an excess of water/brine. Excellent enantioselectivities up to >99% and diastereoselectivities up to 99% with very good yields were obtained by using much lower catalyst loadings (0.5 mol %).
ISSN:1523-7060
1523-7052
DOI:10.1021/ol071013l