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Establishment of a human herpes virus-8-negative malignant effusion lymphoma cell line (STR-428) carrying concurrent translocations of BCL2 and c-MYC genes
Abstract A new cell line, STR-428 was established from ascites tumor cells of a malignant effusion lymphoma patient without human herpes virus-8 (HHV-8) infection. STR-428 cells showed an immunophenotype of mature B-cells and produced few cytokines related to lymphomatous effusion. Karyotypic and ge...
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| Published in: | Leukemia research 2007-09, Vol.31 (9), p.1285-1292 |
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| container_end_page | 1292 |
| container_issue | 9 |
| container_start_page | 1285 |
| container_title | Leukemia research |
| container_volume | 31 |
| creator | Taira, Tamiko Nagasaki, Akitoshi Tomoyose, Takeaki Miyagi, Jun-ichi Kakazu, Naoki Makino, Shigeyoshi Shinjyo, Tetsuharu Taira, Naoya Masuda, Masato Takasu, Nobuyuki |
| description | Abstract A new cell line, STR-428 was established from ascites tumor cells of a malignant effusion lymphoma patient without human herpes virus-8 (HHV-8) infection. STR-428 cells showed an immunophenotype of mature B-cells and produced few cytokines related to lymphomatous effusion. Karyotypic and genetic analysis revealed complex translocations including t (14;18)(q32;q21) effecting IgH / BCL2 and der(8) t (3;8)(q27;q24) involving c-MYC . STR-428 represents a unique, B-cell lymphoma cell line carrying concurrent rearrangement of BCL2 and c-MYC genes with features distinct from those of HHV-8-related primary effusion lymphoma. This cell line may be a valuable tool, other than HHV-8, to investigate the pathogenesis of primary lymphomatous effusion. |
| doi_str_mv | 10.1016/j.leukres.2006.12.023 |
| format | article |
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STR-428 cells showed an immunophenotype of mature B-cells and produced few cytokines related to lymphomatous effusion. Karyotypic and genetic analysis revealed complex translocations including t (14;18)(q32;q21) effecting IgH / BCL2 and der(8) t (3;8)(q27;q24) involving c-MYC . STR-428 represents a unique, B-cell lymphoma cell line carrying concurrent rearrangement of BCL2 and c-MYC genes with features distinct from those of HHV-8-related primary effusion lymphoma. This cell line may be a valuable tool, other than HHV-8, to investigate the pathogenesis of primary lymphomatous effusion.</description><identifier>ISSN: 0145-2126</identifier><identifier>EISSN: 1873-5835</identifier><identifier>DOI: 10.1016/j.leukres.2006.12.023</identifier><identifier>PMID: 17368758</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>B-cell lymphoma ; BCL2 ; Blotting, Southern ; c-MYC ; Cell line ; Chromosomes, Human, Pair 14 - genetics ; Chromosomes, Human, Pair 18 - genetics ; Cytokines ; Hematology, Oncology and Palliative Medicine ; Herpesvirus 8, Human - physiology ; Human herpes virus-8 ; Human herpesvirus 8 ; Humans ; Immunoenzyme Techniques ; Immunophenotyping ; In Situ Hybridization, Fluorescence ; Lymphoma - genetics ; Lymphoma - metabolism ; Lymphoma - virology ; Male ; Malignant effusion lymphoma ; Middle Aged ; Pleural Effusion, Malignant - genetics ; Polymerase Chain Reaction ; Primary effusion lymphoma ; Proto-Oncogene Proteins c-bcl-2 - genetics ; Proto-Oncogene Proteins c-myc - genetics ; Translocation, Genetic ; Tumor Cells, Cultured</subject><ispartof>Leukemia research, 2007-09, Vol.31 (9), p.1285-1292</ispartof><rights>Elsevier Ltd</rights><rights>2007 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-5a755972028f4a846bdd664baf924b404d9f1155c2d8c9a0915a517ed9fc91223</citedby><cites>FETCH-LOGICAL-c511t-5a755972028f4a846bdd664baf924b404d9f1155c2d8c9a0915a517ed9fc91223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17368758$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taira, Tamiko</creatorcontrib><creatorcontrib>Nagasaki, Akitoshi</creatorcontrib><creatorcontrib>Tomoyose, Takeaki</creatorcontrib><creatorcontrib>Miyagi, Jun-ichi</creatorcontrib><creatorcontrib>Kakazu, Naoki</creatorcontrib><creatorcontrib>Makino, Shigeyoshi</creatorcontrib><creatorcontrib>Shinjyo, Tetsuharu</creatorcontrib><creatorcontrib>Taira, Naoya</creatorcontrib><creatorcontrib>Masuda, Masato</creatorcontrib><creatorcontrib>Takasu, Nobuyuki</creatorcontrib><title>Establishment of a human herpes virus-8-negative malignant effusion lymphoma cell line (STR-428) carrying concurrent translocations of BCL2 and c-MYC genes</title><title>Leukemia research</title><addtitle>Leuk Res</addtitle><description>Abstract A new cell line, STR-428 was established from ascites tumor cells of a malignant effusion lymphoma patient without human herpes virus-8 (HHV-8) infection. STR-428 cells showed an immunophenotype of mature B-cells and produced few cytokines related to lymphomatous effusion. Karyotypic and genetic analysis revealed complex translocations including t (14;18)(q32;q21) effecting IgH / BCL2 and der(8) t (3;8)(q27;q24) involving c-MYC . STR-428 represents a unique, B-cell lymphoma cell line carrying concurrent rearrangement of BCL2 and c-MYC genes with features distinct from those of HHV-8-related primary effusion lymphoma. This cell line may be a valuable tool, other than HHV-8, to investigate the pathogenesis of primary lymphomatous effusion.</description><subject>B-cell lymphoma</subject><subject>BCL2</subject><subject>Blotting, Southern</subject><subject>c-MYC</subject><subject>Cell line</subject><subject>Chromosomes, Human, Pair 14 - genetics</subject><subject>Chromosomes, Human, Pair 18 - genetics</subject><subject>Cytokines</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Herpesvirus 8, Human - physiology</subject><subject>Human herpes virus-8</subject><subject>Human herpesvirus 8</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Immunophenotyping</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Lymphoma - genetics</subject><subject>Lymphoma - metabolism</subject><subject>Lymphoma - virology</subject><subject>Male</subject><subject>Malignant effusion lymphoma</subject><subject>Middle Aged</subject><subject>Pleural Effusion, Malignant - genetics</subject><subject>Polymerase Chain Reaction</subject><subject>Primary effusion lymphoma</subject><subject>Proto-Oncogene Proteins c-bcl-2 - genetics</subject><subject>Proto-Oncogene Proteins c-myc - genetics</subject><subject>Translocation, Genetic</subject><subject>Tumor Cells, Cultured</subject><issn>0145-2126</issn><issn>1873-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFks2O0zAQxyMEYrsLjwDyCbGHFI8TO_GFFVTLh1SExC4HTpbjTFp3E7vYSaU-Cy-Lo1ZC4rInS6P_hzy_ybJXQJdAQbzbLXucHgLGJaNULIEtKSueZAuoqyLndcGfZgsKJc8ZMHGRXca4o5RyCfJ5dgFVIeqK14vsz20cddPbuB3QjcR3RJPtNGhHthj2GMnBhinmde5wo0d7QDLo3m6cTmLsuila70h_HPZbP2hisO9Jbx2St3f3P_KS1dfE6BCO1m2I8c5MIcw1Y9Au9t6kRO_i3PpxtWZEu5aY_NuvFdmgw_gie9bpPuLL83uV_fx0e7_6kq-_f_66-rDODQcYc64rzmXFKKu7UtelaNpWiLLRnWRlU9KylR0A54a1tZGaSuCaQ4VpbCQwVlxlb065--B_TxhHNdg4f0U79FNUFRXJBPJRIUhRUCHnRH4SmuBjDNipfbCDDkcFVM341E6d8akZnwKmEr7ke30umJoB23-uM68kuDkJMO3jYDGoaCw6g60NaEbVevtoxfv_EkwCZo3uH_CIceen4NKyFaiYDOpuvqH5hGiVzgfKuvgLTrfDtQ</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>Taira, Tamiko</creator><creator>Nagasaki, Akitoshi</creator><creator>Tomoyose, Takeaki</creator><creator>Miyagi, Jun-ichi</creator><creator>Kakazu, Naoki</creator><creator>Makino, Shigeyoshi</creator><creator>Shinjyo, Tetsuharu</creator><creator>Taira, Naoya</creator><creator>Masuda, Masato</creator><creator>Takasu, Nobuyuki</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20070901</creationdate><title>Establishment of a human herpes virus-8-negative malignant effusion lymphoma cell line (STR-428) carrying concurrent translocations of BCL2 and c-MYC genes</title><author>Taira, Tamiko ; Nagasaki, Akitoshi ; Tomoyose, Takeaki ; Miyagi, Jun-ichi ; Kakazu, Naoki ; Makino, Shigeyoshi ; Shinjyo, Tetsuharu ; Taira, Naoya ; Masuda, Masato ; Takasu, Nobuyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-5a755972028f4a846bdd664baf924b404d9f1155c2d8c9a0915a517ed9fc91223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>B-cell lymphoma</topic><topic>BCL2</topic><topic>Blotting, Southern</topic><topic>c-MYC</topic><topic>Cell line</topic><topic>Chromosomes, Human, Pair 14 - genetics</topic><topic>Chromosomes, Human, Pair 18 - genetics</topic><topic>Cytokines</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Herpesvirus 8, Human - physiology</topic><topic>Human herpes virus-8</topic><topic>Human herpesvirus 8</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Immunophenotyping</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Lymphoma - genetics</topic><topic>Lymphoma - metabolism</topic><topic>Lymphoma - virology</topic><topic>Male</topic><topic>Malignant effusion lymphoma</topic><topic>Middle Aged</topic><topic>Pleural Effusion, Malignant - genetics</topic><topic>Polymerase Chain Reaction</topic><topic>Primary effusion lymphoma</topic><topic>Proto-Oncogene Proteins c-bcl-2 - genetics</topic><topic>Proto-Oncogene Proteins c-myc - genetics</topic><topic>Translocation, Genetic</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taira, Tamiko</creatorcontrib><creatorcontrib>Nagasaki, Akitoshi</creatorcontrib><creatorcontrib>Tomoyose, Takeaki</creatorcontrib><creatorcontrib>Miyagi, Jun-ichi</creatorcontrib><creatorcontrib>Kakazu, Naoki</creatorcontrib><creatorcontrib>Makino, Shigeyoshi</creatorcontrib><creatorcontrib>Shinjyo, Tetsuharu</creatorcontrib><creatorcontrib>Taira, Naoya</creatorcontrib><creatorcontrib>Masuda, Masato</creatorcontrib><creatorcontrib>Takasu, Nobuyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taira, Tamiko</au><au>Nagasaki, Akitoshi</au><au>Tomoyose, Takeaki</au><au>Miyagi, Jun-ichi</au><au>Kakazu, Naoki</au><au>Makino, Shigeyoshi</au><au>Shinjyo, Tetsuharu</au><au>Taira, Naoya</au><au>Masuda, Masato</au><au>Takasu, Nobuyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Establishment of a human herpes virus-8-negative malignant effusion lymphoma cell line (STR-428) carrying concurrent translocations of BCL2 and c-MYC genes</atitle><jtitle>Leukemia research</jtitle><addtitle>Leuk Res</addtitle><date>2007-09-01</date><risdate>2007</risdate><volume>31</volume><issue>9</issue><spage>1285</spage><epage>1292</epage><pages>1285-1292</pages><issn>0145-2126</issn><eissn>1873-5835</eissn><abstract>Abstract A new cell line, STR-428 was established from ascites tumor cells of a malignant effusion lymphoma patient without human herpes virus-8 (HHV-8) infection. STR-428 cells showed an immunophenotype of mature B-cells and produced few cytokines related to lymphomatous effusion. Karyotypic and genetic analysis revealed complex translocations including t (14;18)(q32;q21) effecting IgH / BCL2 and der(8) t (3;8)(q27;q24) involving c-MYC . STR-428 represents a unique, B-cell lymphoma cell line carrying concurrent rearrangement of BCL2 and c-MYC genes with features distinct from those of HHV-8-related primary effusion lymphoma. This cell line may be a valuable tool, other than HHV-8, to investigate the pathogenesis of primary lymphomatous effusion.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>17368758</pmid><doi>10.1016/j.leukres.2006.12.023</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0145-2126 |
| ispartof | Leukemia research, 2007-09, Vol.31 (9), p.1285-1292 |
| issn | 0145-2126 1873-5835 |
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| source | ScienceDirect Journals |
| subjects | B-cell lymphoma BCL2 Blotting, Southern c-MYC Cell line Chromosomes, Human, Pair 14 - genetics Chromosomes, Human, Pair 18 - genetics Cytokines Hematology, Oncology and Palliative Medicine Herpesvirus 8, Human - physiology Human herpes virus-8 Human herpesvirus 8 Humans Immunoenzyme Techniques Immunophenotyping In Situ Hybridization, Fluorescence Lymphoma - genetics Lymphoma - metabolism Lymphoma - virology Male Malignant effusion lymphoma Middle Aged Pleural Effusion, Malignant - genetics Polymerase Chain Reaction Primary effusion lymphoma Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-myc - genetics Translocation, Genetic Tumor Cells, Cultured |
| title | Establishment of a human herpes virus-8-negative malignant effusion lymphoma cell line (STR-428) carrying concurrent translocations of BCL2 and c-MYC genes |
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