Connatal tuberculosis in an extremely low birth weight infant : case report and management of exposure to tuberculosis in a neonatal intensive care unit

A case of connatal tuberculosis in an extremely low birth weight infant is reported. The patient was a female with a birth weight of 973 g born in the 27th week of pregnancy. She developed respiratory distress and signs of infection immediately after birth, which did not respond to mechanical ventil...

Full description

Saved in:
Bibliographic Details
Published in:European journal of pediatrics 2001-02, Vol.160 (2), p.88-90
Main Authors: SAITOH, Mika, ICHIBA, Hiroyuki, FUJIOKA, Hiroki, SHINTAKU, Haruo, YAMANO, Tsunekazu
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Antitubercular Agents - therapeutic use
Biological and medical sciences
Emergency and intensive care: techniques, logistics
Female
Humans
Infant, Newborn
Infant, Very Low Birth Weight
Infection Control - methods
Intensive care medicine
Intensive care unit. Emergency transport systems. Emergency, hospital ward
Intensive Care Units, Neonatal
Isoniazid - therapeutic use
Japan
Medical sciences
Patient Isolation
Tuberculosis - congenital
Tuberculosis - prevention & control
Tuberculosis - therapy
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A case of connatal tuberculosis in an extremely low birth weight infant is reported. The patient was a female with a birth weight of 973 g born in the 27th week of pregnancy. She developed respiratory distress and signs of infection immediately after birth, which did not respond to mechanical ventilation, antibiotics, and corticosteroid therapy. Connatal tuberculosis was confirmed at 48 days of age by isolation of Mycobacterium tuberculosis from the infant's tracheal aspirate and the mother's menstrual discharge. The infant died of respiratory failure at 90 days of age. Mantoux tuberculin skin tests (TST) were performed on 99 infants, 144 medical staff members, and two family members. TST conversion occurred in three medical staff members, and preventive therapy with isoniazid was initiated. Eight exposed infants had normal chest X-rays and negative gastric aspirates for acid-fast bacilli and all received preventive isoniazid therapy. No case of tuberculosis developed during the 2-year follow-up period. Connatal tuberculosis should be considered in neonatal respiratory infection resistant to antibiotics. Prevention of transmission of tuberculosis on the neonatal intensive care unit by chemoprophylaxis is important.
ISSN:0340-6199
1432-1076
DOI:10.1007/s004310000675