PADI4 polymorphisms and rheumatoid arthritis susceptibility: a meta-analysis

We conducted a comprehensive meta-analysis with all available data on the association of allele and genotype of peptidylarginine deiminases 4 (PADI4) polymorphisms with RA overall and in each ethnic population to explore whether the PADI4 polymorphisms confer susceptibility to RA. Nine comparisons,...

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Bibliographic Details
Published in:Rheumatology international 2007-07, Vol.27 (9), p.827-833
Main Authors: Lee, Young Ho, Rho, Young Hee, Choi, Seong Jae, Ji, Jong Dae, Song, Gwan Gyu
Format: Article
Language:English
Subjects:
Arthritis, Rheumatoid - enzymology
Arthritis, Rheumatoid - ethnology
Arthritis, Rheumatoid - genetics
Asians - ethnology
Asians - genetics
DNA Mutational Analysis
Genetic Predisposition to Disease - genetics
Genetic Testing
Genotype
Humans
Hydrolases - genetics
Meta-analysis
Minority & ethnic groups
Polymorphism, Genetic - genetics
Polymorphism, Genetic - immunology
Protein-Arginine Deiminase Type 4
Protein-Arginine Deiminases
Risk Factors
Whites - ethnology
Whites - genetics
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Summary:We conducted a comprehensive meta-analysis with all available data on the association of allele and genotype of peptidylarginine deiminases 4 (PADI4) polymorphisms with RA overall and in each ethnic population to explore whether the PADI4 polymorphisms confer susceptibility to RA. Nine comparisons, three Asians and six Europeans, from eight studies were included in this meta-analysis. Overall meta-analysis shows a significant association of PADI4_94, 104 and 90 with RA (OR = 1.20, 1.17, 1.35, P = 0.001,
ISSN:0172-8172
1437-160X
DOI:10.1007/s00296-007-0320-y