Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor

The use of three orthogonally tagged phosphine reagents to assist chemical work-up via phase-switch scavenging in conjunction with a modular flow reactor is described. These techniques (acidic, basic and Click chemistry) are used to prepare various amides and tri-substituted guanidines from in situ...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2007-05, Vol.5 (10), p.1562-1568
Main Authors: Smith, Christopher D, Baxendale, Ian R, Tranmer, Geoffrey K, Baumann, Marcus, Smith, Stephen C, Lewthwaite, Russell A, Ley, Steven V
Format: Article
Language:English
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Summary:The use of three orthogonally tagged phosphine reagents to assist chemical work-up via phase-switch scavenging in conjunction with a modular flow reactor is described. These techniques (acidic, basic and Click chemistry) are used to prepare various amides and tri-substituted guanidines from in situ generated iminophosphoranes.
ISSN:1477-0520
1477-0539
DOI:10.1039/b703033a