Quorum sensing in Serratia

Many bacteria use cell-cell communication to monitor their population density, synchronize their behaviour and socially interact. This communication results in a coordinated gene regulation and is generally called quorum sensing. In gram-negative bacteria, the most common quorum signal molecules are...

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Bibliographic Details
Published in:FEMS microbiology reviews 2007-07, Vol.31 (4), p.407-424
Main Authors: Van Houdt, Rob, Givskov, Michael, Michiels, Chris W
Format: Article
Language:English
Subjects:
4-Butyrolactone - analogs & derivatives
4-Butyrolactone - metabolism
antibiotica
Bacteria
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Bacteriology
biofilm
Biofilms - growth & development
Biological and medical sciences
cell communication
Cell interactions
cell–cell communication
Chemical communication
Detection
fermentation
Fundamental and applied biological sciences. Psychology
Gene expression
Gene Expression Regulation, Bacterial
Gene regulation
Gram-negative bacteria
Homoserine - analogs & derivatives
Homoserine - genetics
Homoserine - metabolism
Homoserine lactones
Hospitals
Humans
Lactones
Lactones - metabolism
Microbiology
Miscellaneous
N-Acyl homoserine lactone
Nosocomial infection
Phenotypes
Population density
prodigiosin
Quorum Sensing
Serratia
Serratia - genetics
Serratia - growth & development
Serratia - metabolism
Serratia - physiology
Serratia marcescens
Serratia marcescens - genetics
Serratia marcescens - growth & development
Serratia marcescens - metabolism
Signal Transduction
swarming
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Summary:Many bacteria use cell-cell communication to monitor their population density, synchronize their behaviour and socially interact. This communication results in a coordinated gene regulation and is generally called quorum sensing. In gram-negative bacteria, the most common quorum signal molecules are acylated homoserine lactones (AHLs), although other low-molecular-mass signalling molecules have been described such as Autoinducer-2 (AI-2). The phenotypes that are regulated in Serratia species by means of AHLs are remarkably diverse and of profound biological and ecological significance, and often interconnected with other global regulators. Furthermore, AHL- and AI-2-mediated systems (less profoundly studied) are continuously being discovered and explored in Serratia spp., many having interesting twists on the basic theme. Therefore, this review will highlight the current known quorum sensing systems in Serratia spp., including the important nosocomial pathogen Serratia marcescens.
ISSN:0168-6445
1574-6976
1574-6976
DOI:10.1111/j.1574-6976.2007.00071.x