Chronic Hepatitis C: Viral Clearance Several Months after Discontinuation of Therapy in Two Non-responders

When hepatitis C virus (HCV) infection becomes chronic, spontaneous viral eradication is a rare event. We report two patients with chronic hepatitis C, non-responders to standard interferon alone. They were treated with Pegylated interferon plus ribavirin. At the end of therapy, HCV RNA was still de...

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Bibliographic Details
Published in:Infection 2007-06, Vol.35 (3), p.197-200
Main Authors: Denis, J, Rautou, P. E, Lambare, B, Herbert, S, Auray-Cartier, V, Asselah, T
Format: Article
Language:English
Subjects:
Adult
Alanine Transaminase - blood
Drug Administration Schedule
Drug Therapy, Combination
Female
Hepacivirus - drug effects
Hepatitis
Hepatitis C virus
Hepatitis C, Chronic - drug therapy
Humans
Interferon-alpha - pharmacology
Male
Middle Aged
Polyethylene Glycols - pharmacology
Recombinant Proteins
Ribavirin - pharmacology
Treatment Outcome
Viral Load
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Summary:When hepatitis C virus (HCV) infection becomes chronic, spontaneous viral eradication is a rare event. We report two patients with chronic hepatitis C, non-responders to standard interferon alone. They were treated with Pegylated interferon plus ribavirin. At the end of therapy, HCV RNA was still detectable. Several months after stopping treatment, aminotransferase level normalized and HCV RNA became undetectable. No case of sustained viral response happening several months after therapy has been yet described. During long-term follow-up of non-responders, when a persistent normalization of aminotransferase level is observed after stopping treatment, viral clearance could be suspected.
ISSN:0300-8126
1439-0973
DOI:10.1007/s15010-007-6099-7