Relation of Etiology of Heart Failure (Ischemic Versus Nonischemic) Before Transplantation to Delayed Pulmonary Oxygen Uptake Kinetics After Heart Transplantation

• Published in: The American journal of cardiology 2007-06, Vol.99 (12), p.1745-1749
• Main Authors: Tomczak, Corey R., MSc, Jendzjowsky, Nicholas G., BSc, Riess, Kenneth J., MSc, Tymchak, Wayne, MD, Kim, Daniel, MD, Haennel, Robert, PhD, Haykowsky, Mark J., PhD
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biological and medical sciences; Cardiology; Cardiology. Vascular system; Cardiovascular; Case-Control Studies; Exercise Test; Heart; Heart failure; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Heart Transplantation - physiology; Humans; Medical sciences; Middle Aged; Myocardial Ischemia - physiopathology; Myocardial Ischemia - surgery; Oxygen; Pulmonary Gas Exchange - physiology; Studies; Transplants & implants
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2007.01.058

The effect that pretransplantation heart failure cause has on pulmonary oxygen uptake (V̇O2p ) kinetics and peak aerobic power (V̇O2peak ) in heart transplant recipients (HTRs) has not been studied. We examined V̇O2p kinetics and V̇O2peak in HTRs with previous ischemic heart failure (I-HTRs; n = 16, mean age 64 ± 6 years) or nonischemic heart failure (NI-HTRs; n = 13, mean age 50 ± 12 years). HTRs performed an incremental exercise (V̇O2peak ) test and a constant work rate submaximal exercise (V̇O2p kinetics) test. A monoexponential model was used to determine the phase II V̇O2p time constant (τ). Phase II V̇O2p τ was slower in I-HTRs (49 ± 10 seconds) than in NI-HTRs (34 ± 10 seconds) (p