The tissue factor–factor VIIa complex: procoagulant activity, regulation, and multitasking

Greater understanding of the cellular interactions associated with tissue factor (TF), activated factor (F) VII and TF–FVIIa complexes is likely to provide considerable clinical benefit. This article reviews current knowledge on the function and regulation of TF and its role in a range of biological...

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Bibliographic Details
Published in:Journal of thrombosis and haemostasis 2007-06, Vol.5 (6), p.1097-1105
Main Authors: MONROE, D. M., KEY, N. S.
Format: Article
Language:English
Subjects:
activated factor VII
Blood Coagulation - physiology
coagulation
Factor VIIa - chemistry
Factor VIIa - physiology
Hemostasis
Humans
Inflammation - blood
Inflammation - etiology
Lipoproteins - chemistry
Lipoproteins - genetics
Lipoproteins - physiology
Models, Molecular
Multiprotein Complexes
Protein Processing, Post-Translational
Signal Transduction
Solubility
Thromboplastin - chemistry
Thromboplastin - physiology
Thrombosis - blood
Thrombosis - etiology
tissue factor
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Summary:Greater understanding of the cellular interactions associated with tissue factor (TF), activated factor (F) VII and TF–FVIIa complexes is likely to provide considerable clinical benefit. This article reviews current knowledge on the function and regulation of TF and its role in a range of biological processes, including hemostasis, thrombosis and inflammation.
ISSN:1538-7933
1538-7836
1538-7836
DOI:10.1111/j.1538-7836.2007.02435.x