High levels of reticulated platelets and thrombopoietin characterize fetal thrombopoiesis

To characterize fetal thrombopoiesis, we determined plasma thrombopoietin (TPO) and glycocalicin levels, platelet counts and reticulated platelets (RP) of fetuses and compared them with the respective values of their mothers. Percutaneous umbilical vein sampling in abnormal pregnancies revealed twof...

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Bibliographic Details
Published in:British journal of haematology 2001-02, Vol.112 (2), p.466-468
Main Authors: Jilma‐Stohlawetz, P., Homoncik, M., Jilma, B., Folman, C. C., Von Dem Borne, A. E. G. KR, Bernaschek, G., Deutinger, J., Ulm, B., Eppel, W., Panzer, S.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood Platelets - physiology
Cell differentiation, maturation, development, hematopoiesis
Cell physiology
Female
Fetal Blood - chemistry
Fetal Blood - cytology
fetal thrombopoiesis
Fundamental and applied biological sciences. Psychology
glycocalicin
Hematology
Hematopoiesis
Humans
Leukocyte Count
Molecular and cellular biology
Neutrophils - cytology
Platelet Aggregation Inhibitors - analysis
Platelet Glycoprotein GPIb-IX Complex - analysis
Pregnancy
Pregnancy Trimester, Second
reticulated platelets
thrombopoietin
Thrombopoietin - analysis
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Summary:To characterize fetal thrombopoiesis, we determined plasma thrombopoietin (TPO) and glycocalicin levels, platelet counts and reticulated platelets (RP) of fetuses and compared them with the respective values of their mothers. Percutaneous umbilical vein sampling in abnormal pregnancies revealed twofold higher thrombopoietin levels and 20‐fold higher reticulated platelet counts, but lower levels of glycocalicin in fetuses compared with their mothers (P 
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2001.02524.x