Effects of infectious disease on plasma lipids and their diagnostic significance in critical illness

Background  Plasma lipids can be affected by acute illnesses. The present study attempts to characterize the impact of infectious disease on plasma lipids in critical illness. It also aims to determine the value of plasma lipid routine measurements in the diagnosis of infection in critical illness i...

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Bibliographic Details
Published in:European journal of clinical investigation 2007-07, Vol.37 (7), p.573-579
Main Authors: Lüthold, S., Berneis, K., Bady, P., Müller, B.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
APACHE
Biological and medical sciences
Biomarkers
Cholesterol
Cholesterol, HDL - blood
Cholesterol, HDL - metabolism
Communicable Diseases - complications
Critical Illness
Disorders of blood lipids. Hyperlipoproteinemia
Female
General aspects
high-density lipoprotein cholesterol
Humans
infection
lipoprotein
Male
Medical sciences
Metabolic diseases
Middle Aged
plasma lipid
Predictive Value of Tests
Triglycerides - blood
Triglycerides - metabolism
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Summary:Background  Plasma lipids can be affected by acute illnesses. The present study attempts to characterize the impact of infectious disease on plasma lipids in critical illness. It also aims to determine the value of plasma lipid routine measurements in the diagnosis of infection in critical illness in comparison to markers of infection and acute phase reactants. Materials and methods  An observational study was carried out in 101 critically ill patients admitted consecutively to a medical intensive care unit in a university medical centre. Levels of total cholesterol (TC), high‐density lipoprotein cholesterol (HDL‐C), triglycerides (TG), and additional variables were measured in blood samples taken on the day of admission. Results  In critically ill patients significantly lower levels of HDL‐C and TC were found in infectious disease patients compared to non‐infectious disease patients (P 
ISSN:0014-2972
1365-2362
DOI:10.1111/j.1365-2362.2007.01826.x