Effect of intra-arterial papaverine on regional cerebral blood flow in hemodynamically relevant cerebral vasospasm

It remains controversial whether the intra-arterial administration of papaverine (IAP) is effective in reversing vasospasm-associated cerebral hypoperfusion after aneurysmal subarachnoid hemorrhage. The aim of the present study was to continuously assess regional cerebral blood flow (rCBF) during an...

Full description

Saved in:
Bibliographic Details
Published in:Stroke (1970) 2001-02, Vol.32 (2), p.498-505
Main Authors: VAJKOCZY, Peter, HORN, Peter, BAUHUF, Christian, MUNCH, Elke, HUBNER, Ulrich, THOME, Claudius, POECKLER-SCHOENINGER, Christiane, ROTH, Harry, SCHMIEDEK, Peter
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Blood Flow Velocity - drug effects
Blood Pressure - drug effects
Cardiovascular system
Cerebrovascular Circulation - drug effects
Electrodes, Implanted
Female
Humans
Injections, Intra-Arterial
Male
Medical sciences
Microcirculation - diagnostic imaging
Microcirculation - drug effects
Middle Aged
Papaverine - administration & dosage
Pharmacology. Drug treatments
Prospective Studies
Reproducibility of Results
Rheology
Subarachnoid Hemorrhage - complications
Subarachnoid Hemorrhage - diagnostic imaging
Subarachnoid Hemorrhage - physiopathology
Treatment Failure
Ultrasonography, Doppler, Transcranial
Vascular Resistance - drug effects
Vasodilator Agents - administration & dosage
Vasodilator agents. Cerebral vasodilators
Vasospasm, Intracranial - complications
Vasospasm, Intracranial - drug therapy
Vasospasm, Intracranial - physiopathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It remains controversial whether the intra-arterial administration of papaverine (IAP) is effective in reversing vasospasm-associated cerebral hypoperfusion after aneurysmal subarachnoid hemorrhage. The aim of the present study was to continuously assess regional cerebral blood flow (rCBF) during and after IAP with the use of quantitative, bedside thermal diffusion flowmetry. Eight patients with cerebral vasospasm after subarachnoid hemorrhage (mean flow velocity >120 cm/s; angiographic vessel constriction >33%; hemispheric cerebral blood flow [CBF]
ISSN:0039-2499
1524-4628
DOI:10.1161/01.str.32.2.498