Isolation and Structure of Platencin: A FabH and FabF Dual Inhibitor with Potent Broad-Spectrum Antibiotic Activity

Two birds with one stone: Platencin (1) is a novel and potent broad‐spectrum Gram‐positive antibiotic. Whereas platensimycin is a selective inhibitor of FabF, platencin exerts its activity by a novel mode of action by dual inhibition of FabH and FabF.

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2007-01, Vol.46 (25), p.4684-4688
Main Authors: Jayasuriya, Hiranthi, Herath, Kithsiri B., Zhang, Chaowei, Zink, Deborah L., Basilio, Angela, Genilloud, Olga, Diez, Maria Teresa, Vicente, Francisca, Gonzalez, Ignacio, Salazar, Oscar, Pelaez, Fernando, Cummings, Richard, Ha, Sookhee, Wang, Jun, Singh, Sheo B.
Format: Article
Language:English
Subjects:
3-Oxoacyl-(Acyl-Carrier-Protein) Synthase - antagonists & inhibitors
3-Oxoacyl-(Acyl-Carrier-Protein) Synthase - metabolism
Aminophenols - chemistry
Aminophenols - isolation & purification
Aminophenols - pharmacology
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
antibiotics
drug discovery
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - isolation & purification
Enzyme Inhibitors - pharmacology
inhibitors
Microbial Sensitivity Tests
Molecular Structure
natural products
Polycyclic Compounds - chemistry
Polycyclic Compounds - isolation & purification
Polycyclic Compounds - pharmacology
Staphylococcus aureus - enzymology
structure elucidation
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Description
Summary:Two birds with one stone: Platencin (1) is a novel and potent broad‐spectrum Gram‐positive antibiotic. Whereas platensimycin is a selective inhibitor of FabF, platencin exerts its activity by a novel mode of action by dual inhibition of FabH and FabF.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200701058