Three cases of typical aplastic anaemia associated with a Philadelphia chromosome

We report three cases of typical aplastic anaemia (AA) associated with a Philadelphia chromosome. This translocation was detected at the time of diagnosis of AA (one patient) and when overt leukaemia was diagnosed (two patients: one chronic myeloid leukaemia and one acute lymphoblastic leukaemia) af...

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Bibliographic Details
Published in:British journal of haematology 2001-02, Vol.112 (2), p.385-387
Main Authors: Suzan, F., Terré, C., Garcia, I., Bastie, J. N., Baumelou, E., Gluckman, E., Castaigne, S.
Format: Article
Language:English
Subjects:
acute leukaemia
Adult
Anemia, Aplastic - complications
Anemia, Aplastic - genetics
aplastic anaemia
Biological and medical sciences
chronic myeloid leukaemia
Cytogenetic Analysis
Female
Hematologic and hematopoietic diseases
Hematology
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - complications
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
Philadelphia Chromosome
Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Preleukemia - genetics
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22)
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Summary:We report three cases of typical aplastic anaemia (AA) associated with a Philadelphia chromosome. This translocation was detected at the time of diagnosis of AA (one patient) and when overt leukaemia was diagnosed (two patients: one chronic myeloid leukaemia and one acute lymphoblastic leukaemia) after AA therapy and recovery of blood counts. We discuss the literature arguments about considering some cases of AA as preleukaemic disorders and suggest that our cases illustrate the association of AA with a clonal malignant disorder. We conclude that cytogenetic analysis is necessary at diagnosis of AA or after recovery of blood counts.
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2001.02594.x