Procalcitonin (PCT) in patients with abdominal sepsis

To assess the accuracy of procalcitonin as a measure of severity in patients with septic abdominal illnesses and the sepsis syndrome, to compare measurements with those of other inflammatory mediators, and to predict outcome. We carried out a prospective clinical study from 246 patients with infecti...

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Bibliographic Details
Published in:Intensive care medicine 2000-03, Vol.26 Suppl 2 (2), p.S165-S169
Main Authors: Reith, H B, Mittelkötter, U, Wagner, R, Thiede, A
Format: Article
Language:English
Subjects:
APACHE
Bacterial Infections - blood
Bacterial Infections - diagnosis
Bacterial Infections - surgery
Biomarkers - blood
C-Reactive Protein - metabolism
Calcitonin - blood
Calcitonin Gene-Related Peptide
Case-Control Studies
Colon
Female
Humans
Intestinal Perforation - blood
Intestinal Perforation - diagnosis
Male
Pancreatitis - blood
Pancreatitis - diagnosis
Peritonitis - blood
Peritonitis - diagnosis
Predictive Value of Tests
Prognosis
Prospective Studies
Protein Precursors - blood
Sepsis - blood
Sepsis - diagnosis
Sepsis - surgery
Severity of Illness Index
Surgical Wound Infection - blood
Surgical Wound Infection - diagnosis
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Summary:To assess the accuracy of procalcitonin as a measure of severity in patients with septic abdominal illnesses and the sepsis syndrome, to compare measurements with those of other inflammatory mediators, and to predict outcome. We carried out a prospective clinical study from 246 patients with infective or septic episodes confirmed at laparotomy and 66 patients undergoing elective operations who acted as controls. Specimens of blood for measurement of cytokine concentrations determination were obtained daily from septic patients. In the control group specimens were obtained before operation, at the end of operation, and on each of the following days until normal recovery (day 10). Every two weeks up to 3 months for patients with metastases, who were being followed up. Compared with other cytokines such as tumor necrosis factor alphaa and interleukin 6 procalcitonin was closely related to the development of infective and septic complications. 59 of 246 patients (24%) with sepsis died. Procalcitonin concentrations preoperatively [median 2.05 compared with 4.2 ng/ml (p=0.08)] (Mann-Whitney U-test) did not differ, but those on the days 1,4 and at the end differed significantly [day 1: 4.9 compared with 13.8 ng/ml (p
ISSN:0342-4642
1432-1238
DOI:10.1007/bf02900731