Acute effects of peritoneal dialysis with dialysates containing dextrose or dextrose and amino acids on muscle protein turnover in patients with chronic renal failure

Whether changes in substrate and insulin levels that occur during peritoneal dialysis (PD) have effects on muscle protein dynamics was evaluated by studying muscle protein synthesis (PS), breakdown (PB), and net protein balance (NB) by the forearm perfusion method associated with the kinetics of 3H-...

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Bibliographic Details
Published in:Journal of the American Society of Nephrology 2001-03, Vol.12 (3), p.557-567
Main Authors: GARIBOTTO, Giacomo, SOFIA, Antonella, CANEPA, Alberto, SAFFIOTI, Stefano, SACCO, Paolo, SALA, Maria Rita, DERTENOIS, Laura, PASTORINO, Nadia, DEFERRARI, Giacomo, RUSSO, Rodolfo
Format: Article
Language:English
Subjects:
Amino Acids
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Cross-Over Studies
Dialysis Solutions
Emergency and intensive care: renal failure. Dialysis management
Forearm - blood supply
Glucose
Humans
Insulin - blood
Intensive care medicine
Kidney Failure, Chronic - metabolism
Kidney Failure, Chronic - pathology
Kidney Failure, Chronic - therapy
Medical sciences
Muscle Proteins - metabolism
Muscle, Skeletal - metabolism
Muscle, Skeletal - pathology
Organ Size
Peritoneal Dialysis, Continuous Ambulatory - adverse effects
Peritoneal Dialysis, Continuous Ambulatory - methods
Phenylalanine - blood
Regional Blood Flow
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Summary:Whether changes in substrate and insulin levels that occur during peritoneal dialysis (PD) have effects on muscle protein dynamics was evaluated by studying muscle protein synthesis (PS), breakdown (PB), and net protein balance (NB) by the forearm perfusion method associated with the kinetics of 3H-phenylalanine in acute, crossover studies in which PD patients served as their own controls. Studies were performed (1) in the basal state and during PD with dialysates that contained dextrose alone in different concentrations (protocol 1: eight patients), (2) during PD with dialysates that contained dextrose alone or dextrose and amino acids (AA) (protocol 2: five patients), and (3) in time controls (five patients). PD with dextrose alone induced (1) a two- to threefold increase in insulin, as well as a 20 to 25% decrease in AA, mainly BCAA, levels; (2) an insulin-related decline (-18%) in forearm PB (P
ISSN:1046-6673
1533-3450
DOI:10.1681/ASN.V123557