Usefulness of mouse models to study the pathogenesis of Sjögren's syndrome

Sjögren's syndrome (SS) is an autoimmune disorder characterized by ocular and oral dryness as well as systemic manifestations. The immunopathogenesis of SS is complex with different intricate factors. Because of the delay in the appearance of symptoms and due to ethical issues it is very diffic...

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Bibliographic Details
Published in:Oral diseases 2007-07, Vol.13 (4), p.366-375
Main Authors: Soyfoo, MS, Steinfeld, S, Delporte, C
Format: Article
Language:English
Subjects:
Animals
Autoimmune Diseases - immunology
autoimmune exocrinopathy
Chimera
Dentistry
Disease Models, Animal
Humans
Mice
Mice, Inbred ICR
Mice, Inbred MRL lpr
Mice, Inbred NOD
Mice, Inbred NZB
Mice, Inbred Strains
Mice, Knockout
Mice, Transgenic
mouse models
pathogenesis
Sjogren's Syndrome - etiology
Sjogren's Syndrome - genetics
Sjogren's Syndrome - immunology
Sjögren's syndrome
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Summary:Sjögren's syndrome (SS) is an autoimmune disorder characterized by ocular and oral dryness as well as systemic manifestations. The immunopathogenesis of SS is complex with different intricate factors. Because of the delay in the appearance of symptoms and due to ethical issues it is very difficult to study the wide array of factors intervening in the pathogenesis of SS in human patients. To circumvent this problem, different animal models have been elaborated for studying the different subsets of the aspects of the physiopathology of this disease. In this review, we focus on the mouse models that have been established to deepen our insight into the immunopathogenesis of SS.
ISSN:1354-523X
1601-0825
DOI:10.1111/j.1601-0825.2007.01376.x