Selective Functional Exhaustion of Hematopoietic Progenitor Cells in the Bone Marrow of Patients With Postinfarction Heart Failure

• Published in: Journal of the American College of Cardiology 2007-06, Vol.49 (24), p.2341-2349
• Main Authors: Kissel, Christine K., MD, Lehmann, Ralf, MD, Assmus, Birgit, MD, Aicher, Alexandra, MD, Honold, Jörg, MD, Fischer-Rasokat, Ulrich, MD, Heeschen, Christopher, MD, Spyridopoulos, Ioakim, MD, Dimmeler, Stefanie, PhD, Zeiher, Andreas M., MD
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age; Aged; Aged, 80 and over; Biological and medical sciences; Bone Marrow; Bone Marrow Cells - metabolism; Cardiology; Cardiology. Vascular system; Cardiomyopathy; Cardiomyopathy, Dilated - blood; Cardiomyopathy, Dilated - epidemiology; Cardiomyopathy, Dilated - physiopathology; Cardiovascular; Cardiovascular disease; Cell Movement - physiology; Colony-Forming Units Assay; Comorbidity; Cytokines; Diabetes; Drug therapy; Family medical history; Female; Flow Cytometry; Heart; Heart attacks; Heart failure; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Heart Rupture, Post-Infarction; Hematopoietic Stem Cells - metabolism; Humans; Hypertension; Internal Medicine; Male; Matrix Metalloproteinase 9 - blood; Medical sciences; Middle Aged; Myocardial Infarction - complications; Myocardial Ischemia - blood; Myocardial Ischemia - epidemiology; Myocardial Ischemia - physiopathology; Population; Risk factors; Smoking - epidemiology; Vascular endothelial growth factor
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2007.01.095

Selective Functional Exhaustion of Hematopoietic Progenitor Cells in the Bone Marrow of Patients With Postinfarction Heart Failure Christine K. Kissel, Ralf Lehmann, Birgit Assmus, Alexandra Aicher, Jörg Honold, Ulrich Fischer-Rasokat, Christopher Heeschen, Ioakim Spyridopoulos, Stefanie Dimmeler, Andreas M. Zeiher We assessed the number and functional capacity of circulating endothelial progenitor cells (EPCs) and bone marrow-derived hematopoietic stem cells in chronic heart failure (CHF) of ischemic cardiomyopathy (ICM) and nonischemic etiology. The number of EPCs was reduced in CHF, irrespective of its etiology, whereas their migratory capacity was selectively reduced in ICM. The number of bone marrow-derived CD34+ HSC was similar in the 2 CHF populations, but their colony-forming capacity was selectively decreased in ICM. Taken together, we show a selective functional impairment of EPCs and hematopoietic stem cells in ischemic heart failure that may influence ventricular remodeling postinfarction.