Renal and cerebral responses to hypoxemia in the ovine fetus

Mild to moderate hypoxemia without major changes in pH and pCO 2 does not reduce fetal renal blood flow and fetal urine production rate. Other factors such as acidemia, hypercapnia or changes in lung liquid production or fetal swallowing are candidates for the reduced amniotic fluid in the growth re...

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Bibliographic Details
Published in:European Journal of Obstetrics and Gynecology 2001-02, Vol.94 (2), p.186-188
Main Author: Braaksma, Margriethe A.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain - blood supply
Brain - embryology
Cerebral response
Diseases of mother, fetus and pregnancy
Fetal Diseases
Gestational Age
Gynecology. Andrology. Obstetrics
Hippocampus - embryology
Hypoxemia
Kidney - embryology
Medical sciences
Ovine fetus
Pregnancy. Fetus. Placenta
Renal blood flow
Sheep - embryology
Urine production rate
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Summary:Mild to moderate hypoxemia without major changes in pH and pCO 2 does not reduce fetal renal blood flow and fetal urine production rate. Other factors such as acidemia, hypercapnia or changes in lung liquid production or fetal swallowing are candidates for the reduced amniotic fluid in the growth retarded fetus. Mild hypoxemia influences the fetal brain development in that the migration of PKC immunoreactive cells is delayed after a period of 48 h of hypoxemia. This could be due to the fact that under these circumstances the expected compensatory increase in fetal cerebral blood flow was only significant 1 h after the onset of hypoxemia. Further research on the final position of the hippocampal neurons in term lambs, subjected to fetal mild hypoxemia, can give more information on the effects of hypoxemia on the fetal brain.
ISSN:0301-2115
1872-7654
DOI:10.1016/S0301-2115(00)00324-9