Effects of Thiazolidinediones on Differentiation, Proliferation, and Apoptosis

Thiazolidinediones induce adipocyte differentiation and thereby limit proliferative potential; hence, early investigations focused on their ability to modulate cellular proliferation and apoptosis. Several lines of evidence indicate significant thiazolidinedione-mediated antitumor activity. An emerg...

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Bibliographic Details
Published in:Molecular cancer research 2007-06, Vol.5 (6), p.523-530
Main Authors: Chou, Fu-Sheng, Wang, Pei-Shan, Kulp, Samuel, Pinzone, Joseph J
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - pharmacology
Apoptosis
beta Catenin - metabolism
Cell Differentiation
Cell Line, Tumor
Cell Proliferation
differentiation
Drosophila
Drug Screening Assays, Antitumor
Humans
Models, Biological
Models, Genetic
PPAR gamma - metabolism
proliferation
thiazolidinedione
Thiazolidinediones - pharmacology
Wnt
Wnt Proteins - metabolism
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Summary:Thiazolidinediones induce adipocyte differentiation and thereby limit proliferative potential; hence, early investigations focused on their ability to modulate cellular proliferation and apoptosis. Several lines of evidence indicate significant thiazolidinedione-mediated antitumor activity. An emerging view is that some antitumor effects are totally or partially peroxisome proliferator-activated receptor-γ (PPARγ) dependent, whereas others are PPARγ independent. The aim of this review is to examine the current evidence about the molecular mechanisms by which thiazolidinediones augment cellular differentiation, inhibit cellular proliferation, and induce apoptosis. We first address the role of thiazolidinediones and/or PPARγ on Wnt/β-catenin signaling pathway as it affects cellular differentiation and then discuss other pathways that are also involved in differentiation as well as proliferation and apoptosis. (Mol Cancer Res 2007;5(6):523–30)
ISSN:1541-7786
1557-3125
DOI:10.1158/1541-7786.MCR-06-0278