Hepatitis C Virus Load Is Associated with Human Immunodeficiency Virus Type 1 Disease Progression in Hemophiliacs

Hepatitis C virus (HCV) and human immunodeficiency virus type 1 (HIV-1) coinfection is common in hemophiliacs and injection drug users. To assess the interaction between HCV load and HIV-1 disease progression, we examined 207 HIV-1/HCV—coinfected patients. Patients were followed prospectively for ∼7...

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Bibliographic Details
Published in:The Journal of infectious diseases 2001-02, Vol.183 (4), p.589-595
Main Authors: Daar, Eric S., Lynn, Henry, Donfield, Sharyne, Gomperts, Edward, O'Brien, Stephen J., Hilgartner, Margaret W., Hoots, W. Keith, Chernoff, David, Arkin, Steven, Wong, W.-Y., Winkler, Cheryl A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
AIDS
Biological and medical sciences
Blood plasma
CD4 Lymphocyte Count
Child
Disease Progression
Hemophilia
Hemophilia A - virology
Hepacivirus
Hepacivirus - physiology
Hepatitis C
Hepatitis C - complications
Hepatitis C - virology
Hepatitis C virus
HIV
HIV 1
HIV Infections - complications
HIV Infections - mortality
HIV Infections - virology
HIV-1 - physiology
Human immunodeficiency virus 1
Human viral diseases
Humans
Infections
Infectious diseases
Major Articles
Medical sciences
Prospective Studies
RNA
RNA, Viral - blood
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral hepatitis
Viral Load
Viruses
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Summary:Hepatitis C virus (HCV) and human immunodeficiency virus type 1 (HIV-1) coinfection is common in hemophiliacs and injection drug users. To assess the interaction between HCV load and HIV-1 disease progression, we examined 207 HIV-1/HCV—coinfected patients. Patients were followed prospectively for ∼7 years, and annual measurements of CD4+ cell counts and HCV and HIV-1 loads were obtained. Survival analysis was used to define the independent effects of HCV load on HIV-1 progression. After controlling for CD4+ cell count and HIV-1 RNA level, every 10-fold increase in baseline HCV RNA was associated with a relative risk (RR) for clinical progression to acquired immunodeficiency syndrome (AIDS) of 1.66 (95% confidence interval [CI], 1.10–2.51; P = .016) and an RR for AIDS-related mortality of 1.54 (95% CI, 1.03–2.30; P = .036). These findings emphasize the need for further research regarding the use of HIV-1— and HCV-specific therapy in coinfected individuals.
ISSN:0022-1899
1537-6613
DOI:10.1086/318539