Mappain, a New Cytotoxic Prenylated Stilbene from Macaranga mappa

A new prenylated stilbene, mappain (1), was isolated from leaves of Macaranga mappa by bioassay-guided fractionation. The structure was established by application of spectroscopic methods. Mappain is cytotoxic but it appears to be a poor substrate for P-glycoprotein-mediated transport because it is...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2001-01, Vol.64 (1), p.103-105
Main Authors: VAN DER KAADEN, Jacobus E., HEMSCHEIDT, Thomas K., MOOBERRY, Susan L.
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Biological and medical sciences
Drug Screening Assays, Antitumor
Euphorbiaceae - chemistry
General pharmacology
Hawaii
Humans
Magnetic Resonance Spectroscopy
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Leaves - chemistry
Plants, Medicinal - chemistry
Protein Prenylation
Spectrophotometry, Ultraviolet
Stilbenes - chemistry
Stilbenes - pharmacology
Tumor Cells, Cultured
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Summary:A new prenylated stilbene, mappain (1), was isolated from leaves of Macaranga mappa by bioassay-guided fractionation. The structure was established by application of spectroscopic methods. Mappain is cytotoxic but it appears to be a poor substrate for P-glycoprotein-mediated transport because it is equally potent and effective against the drug-sensitive SK-OV-3 and drug-resistant SKVLB-1 ovarian cancer cell lines, exhibiting an IC(50) value of 1.3 microM in both cases.
ISSN:0163-3864
1520-6025
DOI:10.1021/np000265r