Adherence of ovine and human Bordetella parapertussis to continuous cell lines and ovine tracheal organ culture

The adherence of ovine and human isolates of Bordetella parapertussis to ovine and human continuous culture cell lines and to ovine tracheal organ culture was compared. Adherence to non-ciliated respiratory continuous culture cells did not reveal any host-specificity of the isolates. In contrast, ad...

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Bibliographic Details
Published in:FEMS microbiology letters 2001-01, Vol.194 (2), p.197-200
Main Authors: Lund, S.J, Rowe, H.A, Parton, R, Donachie, W
Format: Article
Language:English
Subjects:
Adherence
Animals
Bacterial Adhesion
Bacteriology
Biological and medical sciences
Biotechnology
Bordetella
Bordetella - isolation & purification
Bordetella - physiology
Bordetella parapertussis
Cell culture
Cell Line
Cell lines
Continuous culture
epithelium
Fundamental and applied biological sciences. Psychology
Hemagglutination Tests
Host specificity
Humans
Microbiology
Organ culture
Organ Culture Techniques
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Sheep
Trachea - microbiology
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Summary:The adherence of ovine and human isolates of Bordetella parapertussis to ovine and human continuous culture cell lines and to ovine tracheal organ culture was compared. Adherence to non-ciliated respiratory continuous culture cells did not reveal any host-specificity of the isolates. In contrast, adherence of ovine B. parapertussis strains to ciliated ovine tracheal organ culture was significantly greater than that of human strains. These results indicate that tracheal organ culture is a useful tool for studying host-specific adherence of B. parapertussis and suggest that adherence of B. parapertussis to ciliated epithelia is species-specific making it unlikely that the transfer of B. parapertussis between humans and sheep will result in an infection.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.2001.tb09469.x