Capillary blood pressure in the endocrine and exocrine parenchyma of rat pancreas transplants

Background. Transplantation of isolated organs or cells leads to a functional denervation of the organ, which may cause a hyperperfusion of blood. The current study evaluated to what extent blood perfusion and capillary blood pressures were affected in the transplanted rat pancreas. Methods. Inbred,...

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Bibliographic Details
Published in:Surgery 2001-02, Vol.129 (2), p.196-202
Main Authors: Jansson, Leif, Carlsson, Per-Ola, Bodin, Birgitta, Andersson, Arne, Källskog, Örjan
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Pressure
Capillaries - physiopathology
Intestines - blood supply
Islets of Langerhans - blood supply
Islets of Langerhans - innervation
Liver, biliary tract, pancreas, portal circulation, spleen
Male
Medical sciences
Pancreas - blood supply
Pancreas - innervation
Pancreas Transplantation
Rats
Rats, Inbred WF
Regional Blood Flow
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Time Factors
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Summary:Background. Transplantation of isolated organs or cells leads to a functional denervation of the organ, which may cause a hyperperfusion of blood. The current study evaluated to what extent blood perfusion and capillary blood pressures were affected in the transplanted rat pancreas. Methods. Inbred, male Wistar-Furth rats underwent transplantation with a syngeneic pancreaticoduodenal graft. Four weeks later, blood flow to the native and transplanted pancreases was measured with a microsphere technique. Capillary pressures were measured by direct micropuncture technique. Results. An increased islet blood flow was consistently observed in the transplanted pancreas as compared with the native organ, while whole pancreatic and duodenal blood flow was similar in the native and transplanted organs. The capillary pressure was twice as high in the exocrine pancreas (6-7 mm Hg) of both the native and transplanted glands when compared with that of the islets (approximately 3 mm Hg). There were no differences in the capillary pressures in either the islets or exocrine gland when native and transplanted pancreases were compared. Conclusions. We conclude that the transplanted whole pancreas retains a low islet capillary blood pressure after transplantation despite having a higher islet blood perfusion. (Surgery 2001;129:196-202.)
ISSN:0039-6060
1532-7361
DOI:10.1067/msy.2001.110022