Neurological Disease‐Associated Autoantibodies against an Unknown Protein Encoded by a RES4‐22 Homologous Gene

Screening a human small intestinal library with human serum yielded a clone which encoded a protein res4‐22 the gene of which was highly homologous to a recently described gene located in the Huntington's disease locus. Autoantibodies against res4‐22 (anti‐res4‐22), mainly of the immunoglobulin...

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Bibliographic Details
Published in:Scandinavian journal of immunology 2001-02, Vol.53 (2), p.204-208
Main Authors: Amin, M., Uhlig, H. H., Kamprad, M., Karbe, J., Osman, A. A., Grahmann, F., Hummelsheim, H., Mothes, T.
Format: Article
Language:English
Subjects:
Autoantibodies - blood
Autoantibodies - immunology
Autoantigens - genetics
Autoantigens - immunology
Autoimmune Diseases of the Nervous System - blood
Autoimmune Diseases of the Nervous System - genetics
Autoimmune Diseases of the Nervous System - immunology
Brain Ischemia - blood
Brain Ischemia - immunology
Cerebellum - immunology
Chromosomes, Human, Pair 4 - genetics
Gene Library
Genes
Humans
Huntingtin Protein
Immunoglobulin A - immunology
Intestinal Mucosa - chemistry
Intestine, Small - chemistry
Microscopy, Fluorescence
Muscle, Smooth - chemistry
Myelin Sheath - immunology
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - immunology
Nervous System Diseases - blood
Nervous System Diseases - genetics
Nervous System Diseases - immunology
Nuclear Proteins - genetics
Proteins
res4-22 gene
RES4-22 protein
Schwann Cells - chemistry
Sequence Homology, Nucleic Acid
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Summary:Screening a human small intestinal library with human serum yielded a clone which encoded a protein res4‐22 the gene of which was highly homologous to a recently described gene located in the Huntington's disease locus. Autoantibodies against res4‐22 (anti‐res4‐22), mainly of the immunoglobulin (Ig)A type, were detected in patients with neurological disorders at a higher frequency (18.4%) than in healthy blood donors (8.0%). In neurological patients with cerebral ischaemia anti‐res4‐22 was found significantly more often (47.4%) than in the total group of neurological patients. Anti‐res4‐22 positive sera showed significantly more frequently myelin staining in cerebellum and nerve sections than anti‐res4‐22 negative sera. Our findings demonstrate a new species of human autoantibodies against a newly described protein the function of which is still unknown.
ISSN:0300-9475
1365-3083
DOI:10.1046/j.1365-3083.2001.00839.x