Leg uptake of calcitonin gene-related peptide during exercise in spinal cord injured humans

Exercise‐induced increases in cardiac output (CO) and oxygen uptake (VO2) are tightly coupled, as also in absence of central motor activity and neural feedback from skeletal muscle. Neuromodulators of vascular tone and cardiac function – such as calcitonin gene related peptide (CGRP) – may be of imp...

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Bibliographic Details
Published in:Clinical physiology (Oxford) 2001-01, Vol.21 (1), p.32-38
Main Authors: Kjær, Michael, Mohr, Thomas, Dela, Flemming, Secher, Niels, Galbo, Henrik, Olesen, Hanne Lis, Sørensen, Fin Biering, Schifter, Søren
Format: Article
Language:English
Subjects:
Adult
Bicycling
Biological and medical sciences
blood pressure
Blood Pressure - physiology
Calcitonin Gene-Related Peptide - blood
cardiac output
central command
Cerebrospinal fluid. Meninges. Spinal cord
circulation
Electric Stimulation
Female
functional electrical stimulation
heart rate
Heart Rate - physiology
Humans
Leg
leg blood flow
Male
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Neurology
Oxygen Consumption - physiology
paraplegia
Paraplegia - blood
Paraplegia - physiopathology
Physical Exertion - physiology
Quadriplegia - blood
Quadriplegia - physiopathology
Regional Blood Flow - physiology
Spinal Cord Injuries - blood
Spinal Cord Injuries - physiopathology
Stroke Volume - physiology
tetraplegia
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Summary:Exercise‐induced increases in cardiac output (CO) and oxygen uptake (VO2) are tightly coupled, as also in absence of central motor activity and neural feedback from skeletal muscle. Neuromodulators of vascular tone and cardiac function – such as calcitonin gene related peptide (CGRP) – may be of importance. Spinal cord injured individuals (six tetraplegic and four paraplegic) performed electrically induced cycling (FES) with their paralyzed lower limbs for 29 ± 2 min to fatigue. Voluntary cycling performed both at VO2 similar to FES and at maximal exercise in six healthy subjects served as control. In healthy subjects, CGRP in plasma increased only during maximal exercise (33·8 ± 3·1 pmol l−1 (rest) to 39·5 ± 4·3 (14%, P
ISSN:0144-5979
1365-2281
DOI:10.1046/j.1365-2281.2001.00307.x