Nonrandom chromosome changes in Kaposi sarcoma: cytogenetic and FISH results in a new cell line (KS-IMM) and literature review

• Published in: Cancer genetics and cytogenetics 2001, Vol.124 (1), p.16-19
• Main Authors: Casalone, R., Albini, A., Righi, R., Granata, P., Toniolo, A.
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Chromosome Aberrations - genetics; Dermatology; Humans; Iatrogenic Disease; In Situ Hybridization, Fluorescence; Karyotyping; Medical sciences; Ploidies; Sarcoma, Kaposi - genetics; Tumor Cells, Cultured; Tumors of the skin and soft tissue. Premalignant lesions
• ISSN: 0165-4608; 1873-4456
• DOI: 10.1016/S0165-4608(00)00241-7

The karyotype of a new tumorigenic Kaposi sarcoma (KS)-derived cell line, as defined by cytogenetic and fluorescence in situ hybridization (FISH) analysis is 49,XY,i(1)(q10),i(7)(p10),+i(7) (q10),+der(8)t(8;13)(p11;q11),−13,+del(14)(q22),+der(17)t(1;17)(p13;p13). Our aim was to point out some characteristics and recurrent chromosome changes probably playing a relevant role in the malignant progression of KS, by a comparison of the cytogenetic results obtained in the present study with data from the literature. The interpretation of the cytogenetic results is that KS development occurs by multiple steps: an initial reactive polyclonal cell proliferation is associated with chromosome instability; the cells in a later stage acquire clonal chromosome changes. If many chromosome changes are present, particularly 8q and 1q trisomy, 3p14→pter deletion, 1p13, 13p14.3, 7q22, 8p11, 13q11, and 19q13 band rearrangements, KS acquires a neoplastic aggressive state.