Keeping it in the family: folding studies of related proteins

Investigators have recently turned to studies of protein families to shed light on the mechanism of protein folding. In small proteins for which detailed analysis has been performed, recent studies show that transition-state structure is generally conserved. The number and structures of populated fo...

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Bibliographic Details
Published in:Current Opinion in Structural Biology 2001-02, Vol.11 (1), p.83-93
Main Authors: Gunasekaran, Kannan, Eyles, Stephen J, Hagler, Arnold T, Gierasch, Lila M
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Computer Simulation
Conserved Sequence
contact order
Evolution, Molecular
F-value
Folding
homology
intermediate
Kinetics
Models, Chemical
Models, Molecular
Multigene Family
protein engineering
Protein Folding
stability
transition state
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Summary:Investigators have recently turned to studies of protein families to shed light on the mechanism of protein folding. In small proteins for which detailed analysis has been performed, recent studies show that transition-state structure is generally conserved. The number and structures of populated folding intermediates have been found to vary in homologous families of larger (greater than 100-residue) proteins, reflecting a balance of local and global interactions.
ISSN:0959-440X
1879-033X
DOI:10.1016/S0959-440X(00)00173-1