Molecular mechanisms of blood vessel growth

The basic molecular mechanisms governing how endothelial cells, periendothelial cells and matrix molecules interact with each other and with numerous growth factors and receptors, to form blood vessels have been presented. The many insights gained from this basic knowledge are being extended to furt...

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Bibliographic Details
Published in:Cardiovascular research 2001-02, Vol.49 (3), p.507-521
Main Authors: CONWAY, Edward M, COLLEN, Désiré, CARMELIET, Peter
Format: Article
Language:English
Subjects:
Animals
Arteries
Biological and medical sciences
Blood Vessels - embryology
Blood vessels and receptors
Cell Differentiation
Cell Division
Endothelium, Vascular - embryology
Fundamental and applied biological sciences. Psychology
Gene Expression
Growth Substances - genetics
Growth Substances - physiology
Morphogenesis - physiology
Oxygen - metabolism
Signal Transduction - physiology
Stress, Mechanical
Veins
Vertebrates: cardiovascular system
Yolk Sac - blood supply
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Summary:The basic molecular mechanisms governing how endothelial cells, periendothelial cells and matrix molecules interact with each other and with numerous growth factors and receptors, to form blood vessels have been presented. The many insights gained from this basic knowledge are being extended to further understand pathological angiogenesis associated with disorders such as arterial stenosis, myocardial ischemia, atherosclerosis, allograft transplant stenosis. wound healing and tissue repair. As a result, novel angiogenic and anti-angiogenic molecules are rapid-ly entering the clinic, with the promise of relief from a host of medical disorders.
ISSN:0008-6363
1755-3245
DOI:10.1016/S0008-6363(00)00281-9