Cell-cycle-dependent translational control

Control of translation in eukaryotes occurs mainly at the initiation step. Translation rates in mammals are robust in the G 1 phase of the cell cycle but are low during mitosis. These changes correlate with the activity of several canonical translation initiation factors, which is modulated during t...

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Bibliographic Details
Published in:Current Opinion in Genetics & Development 2001-02, Vol.11 (1), p.13-18
Main Authors: Pyronnet, Stéphane, Sonenberg, Nahum
Format: Article
Language:English
Subjects:
Animals
cap-dependent translation
cell cycle
cyclin
Gene Expression Regulation
internal ribosome entry site
Interphase
Mitosis
Picornaviridae - genetics
Picornaviridae - metabolism
Protein Biosynthesis
RNA Caps
Signal Transduction
translation initiation
Yeasts - genetics
Yeasts - metabolism
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Summary:Control of translation in eukaryotes occurs mainly at the initiation step. Translation rates in mammals are robust in the G 1 phase of the cell cycle but are low during mitosis. These changes correlate with the activity of several canonical translation initiation factors, which is modulated during the cell cycle to regulate translation.
ISSN:0959-437X
1879-0380
DOI:10.1016/S0959-437X(00)00150-7