Salmonella-induced cell death: apoptosis, necrosis or programmed cell death?

Over the past several years, it has become apparent that enteropathogens activate cell death programs. For Salmonella and Shigella species, the induction of cell death is required for pathogenesis, and the mechanisms by which these bacteria induce cell death is an area of intense investigation. Alth...

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Bibliographic Details
Published in:Trends in microbiology (Regular ed.) 2001-02, Vol.9 (2), p.64-67
Main Authors: Boise, Lawrence H, Collins, Carleen M
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Caspase 1 - metabolism
caspase-1
Cell Death
Death effector domain
Humans
IL-1β
Macrophages - microbiology
Mice
Necrosis
Programmed cell death (PCD)
Salmonella
Salmonella - pathogenicity
Salmonella - physiology
Salmonella Infections - microbiology
Salmonella Infections - pathology
Salmonella Infections, Animal - microbiology
Salmonella Infections, Animal - pathology
Shigella
TNF
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Summary:Over the past several years, it has become apparent that enteropathogens activate cell death programs. For Salmonella and Shigella species, the induction of cell death is required for pathogenesis, and the mechanisms by which these bacteria induce cell death is an area of intense investigation. Although initial studies suggested that Salmonella induce cell death through an apoptotic pathway, recent studies demonstrate that cell death occurs through a unique caspase 1-dependent mechanism.
ISSN:0966-842X
1878-4380
DOI:10.1016/S0966-842X(00)01937-5