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Salmonella-induced cell death: apoptosis, necrosis or programmed cell death?
Over the past several years, it has become apparent that enteropathogens activate cell death programs. For Salmonella and Shigella species, the induction of cell death is required for pathogenesis, and the mechanisms by which these bacteria induce cell death is an area of intense investigation. Alth...
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Published in: | Trends in microbiology (Regular ed.) 2001-02, Vol.9 (2), p.64-67 |
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container_title | Trends in microbiology (Regular ed.) |
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creator | Boise, Lawrence H Collins, Carleen M |
description | Over the past several years, it has become apparent that enteropathogens activate cell death programs. For
Salmonella and
Shigella species, the induction of cell death is required for pathogenesis, and the mechanisms by which these bacteria induce cell death is an area of intense investigation. Although initial studies suggested that
Salmonella induce cell death through an apoptotic pathway, recent studies demonstrate that cell death occurs through a unique caspase 1-dependent mechanism. |
doi_str_mv | 10.1016/S0966-842X(00)01937-5 |
format | article |
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subjects | Animals Apoptosis Caspase 1 - metabolism caspase-1 Cell Death Death effector domain Humans IL-1β Macrophages - microbiology Mice Necrosis Programmed cell death (PCD) Salmonella Salmonella - pathogenicity Salmonella - physiology Salmonella Infections - microbiology Salmonella Infections - pathology Salmonella Infections, Animal - microbiology Salmonella Infections, Animal - pathology Shigella TNF |
title | Salmonella-induced cell death: apoptosis, necrosis or programmed cell death? |
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