Clinical picture: occult ectopic ACTH syndrome

A 38-year-old male was diagnosed with Cushing's syndrome. Biochemical tests showed hypokalaemia and hypercortisolaemia, with failure of suppression following high dose dexamethasone, suggesting an ectopic or adrenal source. Adrenocorticotrophic hormone levels were >100 IU/L (normal 3-14 IU/L...

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Bibliographic Details
Published in:The Lancet (British edition) 2001-02, Vol.357 (9254), p.419-419
Main Authors: Cuthbertson, D J, Vinjamuri, S, Bowen-Jones, D
Format: Article
Language:English
Subjects:
ACTH Syndrome, Ectopic - diagnostic imaging
Adrenal Glands - pathology
Adult
Biochemical tests
Carcinoid Tumor - diagnostic imaging
Computed tomography
Cushing Syndrome - diagnostic imaging
Health care
Humans
Hyperplasia
Indium Radioisotopes
Lung Neoplasms - diagnostic imaging
Male
Medical diagnosis
Medical disorders
Neoplasms, Unknown Primary - diagnostic imaging
Octreotide
Radionuclide Imaging
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Summary:A 38-year-old male was diagnosed with Cushing's syndrome. Biochemical tests showed hypokalaemia and hypercortisolaemia, with failure of suppression following high dose dexamethasone, suggesting an ectopic or adrenal source. Adrenocorticotrophic hormone levels were >100 IU/L (normal 3-14 IU/L). Pituitary magnetic resonance imaging was normal as was the chest radiograph, spiral computed tomography and bronchoscopy.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(00)04016-2