DRUG EFFECTS ON THE MECHANICAL PROPERTIES OF LARGE ARTERIES IN HUMANS

SUMMARY 1 Arteries become stiffer with increasing age and various disease states. A complete description of arterial mechanical properties in vivo is not possible, although a number of methods have been used. 2 Detailed discussion in the present review is limited to pulse wave velocity and estimates...

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Bibliographic Details
Published in:Clinical and experimental pharmacology & physiology 2007-07, Vol.34 (7), p.688-693
Main Authors: Hope, Sarah A, Hughes, Alun D
Format: Article
Language:English
Subjects:
arterial stiffness
Arteries - drug effects
Arteries - physiopathology
augmentation index
Biomechanical Phenomena
blood pressure
Blood Pressure - drug effects
Cardiovascular Agents - pharmacology
Cardiovascular Agents - therapeutic use
Cardiovascular Diseases - drug therapy
Cardiovascular Diseases - physiopathology
Clinical Trials as Topic - methods
Compliance
Drug Evaluation, Preclinical - methods
drugs
Humans
Pulsatile Flow - drug effects
pulse wave velocity
Research Design
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Summary:SUMMARY 1 Arteries become stiffer with increasing age and various disease states. A complete description of arterial mechanical properties in vivo is not possible, although a number of methods have been used. 2 Detailed discussion in the present review is limited to pulse wave velocity and estimates of central waveform morphology derived by the application of a generalized arterial transfer function. 3 Many drugs affect these parameters, either increasing or decreasing apparent stiffness. However, the extent to which changes reflect changes in blood pressure rather than more fundamental vessel wall properties remains unclear. Similarly, it is as yet unknown whether determining the need for, or assessing the effectiveness of, drug treatment by the assessment of arterial mechanical properties will offer any advantage and the usefulness of these techniques as routine clinical tools remains to be established.
ISSN:0305-1870
1440-1681
DOI:10.1111/j.1440-1681.2007.04661.x