Peripheral T-cell subsets in patients with reticular and atrophic-erosive oral lichen planus

Objective: Oral lichen planus (OLP) presents with various clinical forms that can be classified into 2 major types: reticular OLP and atrophic-erosive OLP. Our objective was to investigate immunologic differences between these 2 types. Study Design: We investigated possible immunologic differences b...

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Published in:Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2001-02, Vol.91 (2), p.180-188
Main Authors: Rodríguez-Núñez, Ignacio, Blanco-Carrión, Andrés, García, Abel García, Rey, José Gándara
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Atrophy
Biological and medical sciences
CD4-Positive T-Lymphocytes - pathology
Chi-Square Distribution
Complement C3 - immunology
Complement C4 - immunology
Dentistry
Female
Flow Cytometry
HLA-DR Antigens - immunology
Humans
Immunoglobulin A - blood
Immunoglobulin E - blood
Immunoglobulin G - blood
Immunoglobulin M - blood
Leukocyte Common Antigens - immunology
Lichen Planus, Oral - classification
Lichen Planus, Oral - immunology
Lymphocyte Count
Male
Medical sciences
Middle Aged
Non tumoral diseases
Otorhinolaryngology. Stomatology
Statistics as Topic
T-Lymphocyte Subsets - classification
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Objective: Oral lichen planus (OLP) presents with various clinical forms that can be classified into 2 major types: reticular OLP and atrophic-erosive OLP. Our objective was to investigate immunologic differences between these 2 types. Study Design: We investigated possible immunologic differences between 26 patients with reticular OLP and 26 patients with atrophic-erosive OLP. Results: No differences were detected in serum Ig levels or complement levels. However, the mean proportions of CD4+CD45RO+ and DR+ lymphocytes were significantly higher in patients with atrophic-erosive OLP than in patients with reticular OLP, whereas the mean proportion of CD8+CD45RA+ lymphocytes was significantly lower in patients with atrophic-erosive OLP. Conclusion: These findings suggest that the 2 clinical types of OLP might have different immunopathogenic mechanisms. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;91:180-8)
ISSN:1079-2104
1528-395X
DOI:10.1067/moe.2001.110415