Identification of reaction products of methamphetamine and hydrogen peroxide in hair dye and decolorant treatments by high-performance liquid chromatography/mass spectrometry

The effect of hydrogen peroxide, a main component of hair dye and decolorant treatments, on methamphetamine (MA) was studied. Two analytical methods, thin‐layer chromatography (TLC) and high‐performance liquid chromatography/mass spectrometry (LC/MS), were used for the separation and identification...

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Bibliographic Details
Published in:Biomedical chromatography 2001-02, Vol.15 (1), p.45-49
Main Authors: Tanaka, Seishi, Iio, Reiko, Chinaka, Satoshi, Takayama, Nariaki, Hayakawa, Kazuichi
Format: Article
Language:English
Subjects:
Chromatography, High Pressure Liquid - methods
Hair Dyes - chemistry
Hydrogen Peroxide - chemistry
Mass Spectrometry - methods
Methamphetamine - chemistry
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Summary:The effect of hydrogen peroxide, a main component of hair dye and decolorant treatments, on methamphetamine (MA) was studied. Two analytical methods, thin‐layer chromatography (TLC) and high‐performance liquid chromatography/mass spectrometry (LC/MS), were used for the separation and identification of MA derivatives. Mixtures of MA solutions and hydrogen peroxide that had been incubated at 39°C for 24 h were shown to contain para‐hydroxy MA by TLC and para‐, meta‐ and ortho‐hydroxy MAs by LC/MS. In addition, MA N‐oxide and N‐hydroxy MA were found in MA/hydrogen peroxide mixtures immediately after mixing. Therefore, we concluded that MA changed to MA N‐oxide and N‐hydroxy MA before changing to para‐, meta‐ and ortho‐hydroxy MAs. Copyright © 2001 John Wiley & Sons, Ltd. Abbreviations used: AP amphetamine CID collision‐induced dissociation OHMA hydroxy MA MA methamphetamine TIC total ion chromatogram
ISSN:0269-3879
1099-0801
DOI:10.1002/bmc.34