Chlamydia outer membrane protein discovery using genomics

Outer membrane proteins of microbial pathogens serve essential roles in engaging the host environment and can be important immunotherapeutic targets. Because of the difficulty of growing large quantities of chlamydiae suitable for biochemical fractionation, little was known about their outer membran...

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Bibliographic Details
Published in:Current Opinion in Microbiology 2001-02, Vol.4 (1), p.16-20
Main Authors: Stephens, Richard S, Lammel, Claudia J
Format: Article
Language:English
Subjects:
Bacterial Outer Membrane Proteins - genetics
Bacterial Proteins
Chamydia
Chlamydia - genetics
Chlamydia pneumoniae
Chlamydia trachomatis
Chlamydia trachomatis - genetics
Chlamydophila pneumoniae - genetics
Gene
Genome
Genome, Bacterial
Genomics
Open reading frames
Outer membrane protein
Polymorphism, Genetic
Porin
Porins - genetics
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Summary:Outer membrane proteins of microbial pathogens serve essential roles in engaging the host environment and can be important immunotherapeutic targets. Because of the difficulty of growing large quantities of chlamydiae suitable for biochemical fractionation, little was known about their outer membrane protein composition prior to the recent sequencing of the C. trachomatis and C. pneumoniae genomes. Using bioinformatic approaches to characterize chlamydial open reading frames, novel outer membrane proteins were predicted. Several of the predicted outer membrane proteins recently have been shown to be translated and localized to the surface of the chlamydial outer membrane.
ISSN:1369-5274
1879-0364
DOI:10.1016/S1369-5274(00)00158-2