Hypoxia-imaging with (18)F-Misonidazole and PET: changes of kinetics during radiotherapy of head-and-neck cancer

PET with (18)F-Misonidazole (FMISO-PET) is a non-invasive method for measuring tumor hypoxia. We analysed changes of FMISO-uptake during radiotherapy and their impact on patient outcome. Fourteen patients with HNC underwent repeated FMISO-PET prior to radiotherapy and after 30Gy. Dynamic and static...

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Published in:Radiotherapy and oncology 2007-06, Vol.83 (3), p.406-410
Main Authors: Eschmann, Susanne Martina, Paulsen, Frank, Bedeshem, Claudia, Machulla, Hans-Jürgen, Hehr, Thomas, Bamberg, Michael, Bares, Roland
Format: Article
Language:English
Subjects:
Aged
Carcinoma, Squamous Cell - diagnostic imaging
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - radiotherapy
Cell Hypoxia
Female
Fluorine Radioisotopes
Head and Neck Neoplasms - diagnostic imaging
Head and Neck Neoplasms - metabolism
Head and Neck Neoplasms - radiotherapy
Humans
Kinetics
Male
Middle Aged
Misonidazole - pharmacokinetics
Positron-Emission Tomography - methods
Prospective Studies
Radiation-Sensitizing Agents - pharmacokinetics
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container_issue 3
container_start_page 406
container_title Radiotherapy and oncology
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creator Eschmann, Susanne Martina
Paulsen, Frank
Bedeshem, Claudia
Machulla, Hans-Jürgen
Hehr, Thomas
Bamberg, Michael
Bares, Roland
description PET with (18)F-Misonidazole (FMISO-PET) is a non-invasive method for measuring tumor hypoxia. We analysed changes of FMISO-uptake during radiotherapy and their impact on patient outcome. Fourteen patients with HNC underwent repeated FMISO-PET prior to radiotherapy and after 30Gy. Dynamic and static PET-scans (2+4h p.i.) were acquired. FMISO-uptake was quantified by calculating standard uptake values (SUV) and tumor-muscle-ratios (TMR). Kinetic curve types representing tissue hypoxia were defined. Change of curve type was correlated with patient outcome. The mean SUV 4h p.i. and the TMR decreased significantly during radiotherapy. SUV decreased clearly in 12/14 patients, and increased in 2 patients. TMR decreased in 11 patients, and increased in 3 patients. Prior to radiotherapy, three different shapes of kinetic curve types indicative for the degree of hypoxia could be defined in 12/14 patients: (1) accumulation type (severe hypoxia (n=8)), (2) intermediate type (intermediate degree of hypoxia (n=3)), and (3) wash-out type (low degree of hypoxia (n=1)). Curve type changed towards a lower degree of hypoxia at 30Gy in all but 3 patients. In three patients curve type remained unchanged. The changes in tumor FMISO-uptake during radiotherapy indicate radio-induced reoxygenation.
doi_str_mv 10.1016/j.radonc.2007.05.014
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subjects Aged
Carcinoma, Squamous Cell - diagnostic imaging
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - radiotherapy
Cell Hypoxia
Female
Fluorine Radioisotopes
Head and Neck Neoplasms - diagnostic imaging
Head and Neck Neoplasms - metabolism
Head and Neck Neoplasms - radiotherapy
Humans
Kinetics
Male
Middle Aged
Misonidazole - pharmacokinetics
Positron-Emission Tomography - methods
Prospective Studies
Radiation-Sensitizing Agents - pharmacokinetics
title Hypoxia-imaging with (18)F-Misonidazole and PET: changes of kinetics during radiotherapy of head-and-neck cancer
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