Molecular epidemiology of tuberculosis and other mycobacterial infections: main methodologies and achievements

. van Soolingen D (National Institute of Public Health and the Environment, Bilthoven, The Netherlands). Molecular epidemiology of tuberculosis and other mycobacterial infections: main methodologies and achievements (Review). J Intern Med 2001; 249: 1–26. In the last decade, DNA fingerprint techniqu...

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Bibliographic Details
Published in:Journal of internal medicine 2001-01, Vol.249 (1), p.1-26
Main Author: Van Soolingen, D.
Format: Article
Language:English
Subjects:
Analysis. Health state
Animals
Bacterial diseases
Biological and medical sciences
Contact Tracing
DNA Fingerprinting
DNA, Bacterial - genetics
Epidemiology
General aspects
Genetics, Microbial - trends
Genotype
Human bacterial diseases
Humans
Infectious diseases
Medical sciences
Molecular Epidemiology - methods
Mycobacterium
Mycobacterium - classification
Mycobacterium - genetics
Mycobacterium - isolation & purification
Mycobacterium Infections, Nontuberculous - epidemiology
Mycobacterium Infections, Nontuberculous - genetics
Mycobacterium Infections, Nontuberculous - transmission
Mycobacterium tuberculosis - genetics
Nontuberculous Mycobacteria - genetics
Polymorphism, Restriction Fragment Length
Public health. Hygiene
Public health. Hygiene-occupational medicine
Reproducibility of Results
RNA, Bacterial - genetics
Sequence Analysis, DNA
Sequence Analysis, RNA
Transformation, Bacterial
transmission
tuberculosis
Tuberculosis - epidemiology
Tuberculosis - genetics
Tuberculosis - transmission
Tuberculosis and atypical mycobacterial infections
Tuberculosis, Multidrug-Resistant - epidemiology
typing
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Summary:. van Soolingen D (National Institute of Public Health and the Environment, Bilthoven, The Netherlands). Molecular epidemiology of tuberculosis and other mycobacterial infections: main methodologies and achievements (Review). J Intern Med 2001; 249: 1–26. In the last decade, DNA fingerprint techniques have become available to study the interperson transmission of tuberculosis and other mycobacterial infections. These methods have facilitated epidemiological studies at a population level. In addition, the species identification of rarely encountered mycobacteria has improved significantly. This article describes the state of the art of the main molecular typing methods for Mycobacterium tuberculosis complex and non‐M. tuberculosis complex (atypical) mycobacteria. Important new insights that have been gained through molecular techniques into epidemiological aspects and diagnosis of mycobacterial diseases are highlighted.
ISSN:0954-6820
1365-2796
DOI:10.1046/j.1365-2796.2001.00772.x