Effects of early use of atenolol or captopril on infarct size and ventricular volume : A double-blind comparison in patients with anterior acute myocardial infarction

beta-Blockers and ACE inhibitors reduce early mortality when either one is started in the first hours after myocardial infarction (MI). Considering the close correlation between morphological changes and prognosis, we aimed to investigate whether the benefit of both beta-blockers and ACE inhibitors...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2001-02, Vol.103 (6), p.813-819
Main Authors: GALCERA-TOMAS, José, CASTILLO-SORIA, Francisco José, LOPEZ-MARTINEZ, Iluminada, INIGO-GARCIA, Luis, PICO-ARACIL, Francisco, VILLEGAS-GARCIA, Manuel, FLORENCIANO-SANCHEZ, Rafael, SANCHEZ-VILLANUEVA, José Ginés, NUNO DE LA ROSA, José Antonio, MARTINEZ-CABALLERO, Antonio, VALENTI-ALDEGUER, José Antonio, JARA-PEREZ, Pedro, PARRAGA-RAMIREZ, Manuel
Format: Article
Language:English
Subjects:
Acute Disease
Adrenergic beta-Antagonists - therapeutic use
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Atenolol - therapeutic use
Biological and medical sciences
Blood Pressure
Captopril - therapeutic use
Cardiovascular system
Coronary Angiography
Double-Blind Method
Drug Therapy, Combination
Echocardiography
Female
Heart - drug effects
Heart - physiopathology
Heart Rate
Humans
Male
Medical sciences
Middle Aged
Myocardial Infarction - diagnostic imaging
Myocardial Infarction - drug therapy
Myocardial Infarction - physiopathology
Myocardium - pathology
Pharmacology. Drug treatments
Prospective Studies
Stroke Volume
Tomography, Emission-Computed, Single-Photon
Vasodilator agents. Cerebral vasodilators
Ventricular Function - drug effects
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Summary:beta-Blockers and ACE inhibitors reduce early mortality when either one is started in the first hours after myocardial infarction (MI). Considering the close correlation between morphological changes and prognosis, we aimed to investigate whether the benefit of both beta-blockers and ACE inhibitors might reside in a similar protective effect on infarct size or ventricular volume. In a randomized, double-blind comparison between early treatment with captopril or atenolol in 121 patients with acute anterior MI, both drugs showed a similar reduction in mean blood pressure. However, only the atenolol-treated patients showed a significant early reduction in heart rate. Infarct size, obtained from the perfusion defect in resting single photon emission imaging, was higher in captopril-treated patients than in atenolol-treated patients: 29.8+/-12% versus 20.8+/-12% (P:
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.103.6.813